- Affinity Purified from Pooled Serum
- Species Tested:
- Expected Reactivity:
- Mouse, Bovine, Canine, Chicken, Human, Non-human primate, Zebra fish
- WB 1:1000ICC 1:400 Don't see your application?
- Host Species:
- Gene Name:
- Molecular Weight:
- ~62 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p1570-202, RRID:AB_2492252
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr202 of synaptotagmin.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns
Biological Significance: ExpandCollapse
Synaptotagmin is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis (Fernandez-Chacon et al., 2001; Wang et al., 2003). Moreover, recent studies indicate that the protein also plays a key role in endocytosis (Poskanzer et al., 2003). Synaptotagmin can be phosphorylated by multiple protein kinases and this may play a key role in modulation of synaptotagmin’s ability to influence both the exocytotic and endocytotic components of synaptic transmission (Hilfiker et al., 1999; Lee et al., 2004).
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