The Colorado Bioscience Association highlights PhosphoSolutions for driving scientific breakthroughs with research antibodies
Founder and CEO Mike Browning receives the prestigious CiteAb Lifetime Achievement Award
We’re thrilled to announce that Dr. Michael Browning, founder and CEO of PhosphoSolutions, has been named winner of the prestigious CiteAb Lifetime Achievement Award 2020. In a career spanning four decades, Dr. Browning has served the cause of scientific discovery as an exemplary neuroscientist, mentor, and business leader.
The Denver Post featured PhosphoSolutions in a front page article!
Antibodies that Work Again and Again and Again
10 February 2017
Authors: Kameron Simpson, Michael Browning
PhosphoSolutions addresses the reproducibility crisis by discussing some of the biggest contributing factors to the “antibody problem”, including steps that can be taken on both the production side as well as on the side of the end-user. We go in-depth to discuss the initial screening via Western Blot that should be done by researchers to confirm antibody quality. We then describe steps that should be taken by producers of polyclonal antibodies to ensure lot-to-lot consistency.
Letter to the Editor of Nature Methods from founder Mike Browning: Should we ignore Western blots when selecting antibodies for other applications?
28 February 2017
An antibody may behave differently in different applications, and it is important to validate the antibody in an application-specific manner. However, Western blotting plays a vital role in establishing the potential for cross reactivity of an antibody, and should not be excluded from the validation process even if the final goal is for the antibody to be used in IHC or IF.
PLoS Review Finds our FMRP ser499 to Have Superior Specificity
18 November 2015
Independent researchers writing for PLoS compared our FMRP phospho-antibody to another commercially available FMRP antibody. The results were clear: The PhosphoSolutions antibody had greater specificity and less variability.
F1000 Research published The Antibody Two-Step Solution
15 September 2015
Author: Michael D. Browning
The scientific community is putting an increasing focus on antibody inconsistency. We believe that these issues can be overcome by addressing two of the biggest offenders: antibody validation and antibody variability. Antibody suppliers must address the variability problem so that scientists can provide validation.
We call this the Antibody Two-Step Solution.
Nature Methods featured CEO Mike Browning in: Finding the Right Antibody for the Job
30 July 2013
Antibody based assays are a crucial part of research labs around the world. A variety of factors such as the variability inherent in biology, differences in applications, and the structure of the antibody marketplace make the quest for quality antibodies a difficult one. Our founder was interviewed to address these issues and provide tips for researchers who are looking for antibodies that work.
Optimized Protocol to Make Phospho-Specific Antibodies that Work
24 January 2011
Authors: Amy J. Archuleta, Crystal A. Stutzke, Kristin M. Nixon, Michael D. Browning
PhosphoSolutions goes in-depth to discuss the essential protocols and methods necessary to create a phospho-specific antibody that works. We describe techniques used from the beginning to the end of the antibody development process. We start with antigen design and immunization, continue with antibody purification, and even discuss the best ways to characterize the phosphospecificity of the antibody in peptide ELISA and western blots.
What makes us different?
- If we attempt to make an antibody and it doesn’t work, we throw it away. We never sell an antibody that we can’t get to work in our hands.
- Our commitment to strict validation standards ensures a clean signal in endogenous protein and verifies phosphospecificity for relevant products.
- We are dedicated to reproducibility. Look for our “Pooled Serum” icon. Each antibody with this icon is purified from its own pool of serum to ensure lot-to-lot consistency.
- We guarantee our antibodies. If you can’t get the antibody to work in your application, we will provide a 100% refund.
- When making a custom antibody, we provide personalized customer support from start to finish, from peptide design, to purification, to characterization.