- Affinity Purified from Pooled Serum
- Species Tested:
- Human, Mouse, Rat
- Expected Reactivity:
- WB 1:1000 Don't see your application?
- Host Species:
- Rabbit Polyclonal
- Gene Name:
- Molecular Weight:
- ~78 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p1560-6267, RRID:AB_2492245
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser62,67 of synapsin I.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogenesis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser549 along with Ser62 and Ser67 are the sites of Synapsin I that are phosphorylated by MAP kinase (Czernik et al., 1987; Jovanovic et al., 1996).