Prox1 Antibody

Catalog #: 1685-PROX1 Categories: , , Datasheet:

$109.00$365.00

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Great for IHC labeling of A II amacrine cells!

Formulation:
Protein G Purified
100% Homology:
Rat, Mouse, Human, Chicken
Applications:
IHC 1:1,000
Species:
Mouse monoclonal
Gene Name:
PROX1
Cite This Antibody:
PhosphoSolutions Cat# 1685-PROX1, RRID:AB_2492217
Antigen/Purification: ExpandCollapse

The antigen is a recombinant human Prox1 protein.

The antibody is a Protein G purified culture supernatant.

Biological Significance: ExpandCollapse

Prox1 (Prospero-related homeobox 1) is a divergent homeogene that regulates cell proliferation, fate determination and differentiation during vertebrate embryonic development. The protein is expressed in the developing lens and is also detected in embryonic brain, lung, liver and kidney; while in adult it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas (Chen et al., 2006). Prox1 is thought to play a fundamental role in early development of the CNS and may regulate gene expression and development of postmitotic undifferentiated young neurons (Misra et al., 2008)

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Xiaoren Chen, Tapan P. Patel, William J. Cain, Melinda K. Duncan. Production of monoclonal antibodies against Prox1. Hybridoma (2006) Feb;25(1):27-33.

Misra K, Gui H, Matise MP (2008) Prox1 regulates a transitory state for interneuron neurogenesis in the spinal cord. Dev Dyn 237(2):393-402.

Prox1 Antibody
Immunostaining of rat dentate gyrus showing specific immunolabeling of the prox1 protein. Photo courtesy of Justin Kievits and Teresa Milner, Weill Cornell Medical College.

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