Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- Species Tested:
- Mouse, Rat
- Expected Reactivity:
- Human, Bovine, Chicken, Non-human primate, Canine
- WB 1:1000 Don't see your application?
- Gene Name:
- Molecular Weight:
- ~32 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p1025-34, RRID:AB_2492068
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr34 of rat DARPP-32.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
DARPP-32 is a dopamine (DA) and cAMP-regulated ~32k phosphoprotein that is associated with dopaminoceptive neurons (Fienberg et al., 1998). The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA (Bibb et al., 1999). Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac® (Maldve et al., 2002; Lindskog et al., 2002; Svenningsson et al., 2002).
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