Our Anti-PEBP (phosphatidylethanolamie binding protein) primary antibody from PhosphoSolutions is rabbit polyclonal. It detects rat PEBP (phosphatidylethanolamie binding protein) and is neat serum. It is great for use in WB.
Phosphatidylethanolamine binding protein (PEBP), also known as Raf kinase inhibitory protein (RKIP) is a highly conserved multifunctional protein that modulates the Raf/MAPK signaling cascade and has been implicated as a suppressor of metastatic cancer (Trakul N et al., 2005). PEBP has been shown to not only inhibit cell proliferation but also to induce differentiation of human keratinocytes (Yamazaki et al., 2004). Dysregulation of calpain activity results in cellular degeneration in conditions such as Alzheimer’s disease and recently PEBP has been identified as a potential in vivo calpain substrate (Chen at al., 2006).
Purified native rat PEBP
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
WB Brain: 1:1000
Specific for endogenous levels of the ~22 kDa PEBP protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Epididymis luminal protein 210 antibody, Epididymis secretory protein Li 34 antibody, Epididymis secretory protein Li 96 antibody, HCNP antibody, HCNPpp antibody, HEL 210 antibody, HEL S 34 antibody, HEL S 96 antibody, Hippocampal cholinergic neurostimulating peptide antibody, Neuropolypeptide h3 antibody, PBP antibody, PEBP antibody, PEBP 1 antibody, PEBP-1 antibody, Pebp1 antibody, PEBP1_HUMAN antibody, Phosphatidylethanolamine binding protein antibody, Phosphatidylethanolamine binding protein 1 antibody, Prostatic binding protein antibody, Prostatic-binding protein antibody, R kip antibody, Raf kinase inhibitor protein antibody, Raf kinase inhibitory protein antibody, RKIP antibody
UniProt (Immunogen Species): P31044
Trakul, N., Menard, R.E., Schade, G.R., Qian, Z. and Rosner, M.R., 2005. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. Journal of Biological Chemistry, 280(26), pp.24931-24940. PMID: 15886202
Yamazaki, T., Nakano, H., Hayakari, M., Tanaka, M., Mayama, J. and Tsuchida, S., 2004. Differentiation induction of human keratinocytes by phosphatidylethanolamine-binding protein. Journal of Biological Chemistry, 279(31), pp.32191-32195. PMID: 15155742
Chen, Q., Wang, S., Thompson, S.N., Hall, E.D. and Guttmann, R.P., 2006. Identification and characterization of PEBP as a calpain substrate. Journal of Neurochemistry, 99(4), pp.1133-1141. PMID: 17018026
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