Western blot of HeLa cell lysate showing specific immunolabeling of the ~60 kDa HSP60 protein.
HSP60 is a member of the heat shock protein family which is thought to play a key role in mitochondrial protein transport and proper refolding of proteins imported from the cytoplasm into the mitochondrial matrix (Koll et al., 1992). More recently, HSP60 has been implicated in the pathogenesis of cardiovascular disease (Rizzo et al., 2011).
Koll, H., Guiard, B., Rassow, J., Ostermann, J., Horwich, A.L., Neupert, W. and Hartl, F.U., 1992. Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space. Cell, 68(6), pp.1163-1175. PMID: 1347713
Rizzo, M., JL Macario, A., Conway de Macario, E., Gouni-Berthold, I., K Berthold, H., Battista Rini, G., Zummo, G. and Cappello, F., 2011. Heat shock protein-60 and risk for cardiovascular disease. Current Pharmaceutical Design, 17(33), pp.3662-3668. PMID: 22074436
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