Our Anti-GABAA Receptor ß1 primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse and rat GABAA Receptor ß1 and is antigen affinity purified from pooled serum. It is great for use in WB.
Western blot of mouse whole brain lysates showing specific immunolabeling of the ~55 kDa β1-subunit of the GABAA-R.
Anti-GABAA Receptor ß1 Antibody
Bulk Order Anti-GABAA Receptor ß1 Antibody
GABAA Receptor ß1
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).
Antigen Affinity Purified from Pooled Serum
Fusion protein from the cytoplasmic loop of the ß1 subunit of rat GABAA receptor.