Name: Anti-COBRA1 (NELF-B) Antibody
Brand: PhosphoSolutions
SKU: 319-COBRA
Price: 415.0 USD
Availability: InStock

Our Anti-COBRA1 (NELF-B) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat COBRA1 (NELF-B) and is Protein G purified. It is great for use in WB.

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

F7E4

Applications

WB

Host Species

Mouse

Format

Protein G Purified

Gene Name

COBRA1

Molecular Weight

62 kDa

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Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~62 kDa COBRA1 protein.

Volume: 100 µL

Variant

Price:

$415

Quantity:

Bulk Order Anti-COBRA1 (NELF-B) Antibody

Product Details

Target

COBRA1 (NELF-B)

Target Description

COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004)

Format

Protein G Purified

Clonality

Monoclonal

Clone

F7E4

Isotype

IgG1

Applications

WB

Host Species

Mouse

Gene Name

COBRA1

Molecular Weight

62 kDa

Antigen

Recombinant full length human COBRA1 purified from E. coli.

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2492059

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Production Notes

Protein G purified culture supernatant.

Buffer

PBS + 0.05% NaN3

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~62 kDa COBRA1 protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

A730008L03Rik antibody, AB041607 antibody, AI663983 antibody, Cofactor of BRCA1 antibody, DKFZp586B0519 antibody, KIAA1182 antibody, Negative elongation factor B antibody, Negative elongation factor protein B antibody, Nelf b antibody, NELF-B antibody, NELFB antibody, RGD1307832 antibody, RP13-122B23.3 antibody, RP23-132N23.4 antibody

UniProt Details

UniProt (Human): Q8WX92
UniProt (Immunogen Species): Q8WX92

NCBI Gene ID

25920

Product Specific Protocols

Western Blot Protocol: Download

General References

Aiyar, SE, Sun J, Blair AL, Moskaluk CA, Lu Y, Ye Q, Yamaguchi Y, Mukherjee A, Ren D, Handa H, Li R (2004). Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev. 18 (17): 2134–46. PMID: 15342491
Zhong, H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Qi (2004). COBRA1 inhibits AP-1 transcriptional activity in transfected cells. Biochem. Biophys. Res. Commun. 325 (2): 568–73.PMID: 15530430

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Anti-COBRA1 (NELF-B) Antibody (F7E4)

Our Anti-COBRA1 (NELF-B) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat COBRA1 (NELF-B) and is Protein G purified. It is great for use in WB.

Anti-COBRA1 (NELF-B) Antibody
SKU: 319-COBRA

Bulk Order Anti-COBRA1 (NELF-B) Antibody

Product Details

Product Specific Protocols

General References

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Anti-COBRA1 (NELF-B) Antibody (F7E4)

Our Anti-COBRA1 (NELF-B) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat COBRA1 (NELF-B) and is Protein G purified. It is great for use in WB.

Anti-COBRA1 (NELF-B) Antibody SKU: 319-COBRA

Bulk Order Anti-COBRA1 (NELF-B) Antibody

Product Details

Product Specific Protocols

General References

Anti-COBRA1 (NELF-B) Antibody
SKU: 319-COBRA