Anti-Caspase-8 (C-terminal region) Antibody (M382)

Name: Anti-Caspase-8 (C-terminal region) Antibody
Brand: PhosphoSolutions
SKU: CM3821
Price: 255.0 USD
Availability: InStock

from PhosphoSolutions

Product Type

Primary Antibody

Species Reactivity

Human

Clone

M382

Applications

Host Species

Mouse

Format

Protein A Purified

Gene Name

CASP8

Molecular Weight

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Western blot analysis of Caspase expression in human Jurkat cells. The blot was probed with anti-Caspase-3 at 1:500 (lane 1) and 1:1000 (lane 2), anti-Caspase-6 at 1:250 (lane 3) and 1:500 (lane 4), anti-Caspase-7 at 1:500 (lane 5) and 1:1000 (lane 6), as well as anti-Caspase-8 at 1:250 (lane 7) and 1:500 (lane 8).

Volume: 100 µL

Variant

Price:

$255

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Product Details

Target

Caspase-8 (C-terminal region)

Target Description

The caspases are a group of cysteine enzymes, which cleave proteins in response to intrinsic and extrinsic pathways that cause apoptotic cell death. The caspases can be grouped into two subgroups based on their roles in apoptosis. Initiator caspases (caspases 2, 8, 9, and 10) are activated through the apoptosis-signaling pathways and activate the effector caspases (caspases 3, 6, and 7) which carry out apoptosis. Caspase cascades are initiated through assembly of multiprotein complexes that trigger activation of the initiator caspases, which are then released and are able to activate the downstream effector caspases.

Format

Protein A Purified

Clonality

Monoclonal

Clone

M382

Isotype

IgG2a

Applications

Host Species

Mouse

Gene Name

CASP8

Molecular Weight

Antigen

Clone (M382) was generated from a recombinant protein containing amino acid residues in the C-terminal region of human Caspase-8.

Species Reactivity

Human

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Dilution Ranges

WB: 1:500

Conjugate

Unconjugated

Specificity

The antibody detects a 55 kDa* protein corresponding to the molecular weight of Caspase-8 on SDS-PAGE immunoblots of human Jurkat, K562, and A431 cells.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Caspase-8, ced3, NEDD2-like protein,p15, p10

UniProt Details

UniProt (Human): Q14790
UniProt (Immunogen Species): Q14790

Product Specific Protocols

Western Blot Protocol: Download

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Anti-Caspase-8 (C-terminal region) Antibody (M382)

Anti-Caspase-8 (C-terminal region) Antibody
SKU: CM3821

Bulk Order Anti-Caspase-8 (C-terminal region) Antibody

Product Details

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Anti-Caspase-8 (C-terminal region) Antibody (M382)

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Bulk Order Anti-Caspase-8 (C-terminal region) Antibody

Product Details

Product Specific Protocols

Anti-Caspase-8 (C-terminal region) Antibody
SKU: CM3821