Western blot of rat liver showing specific immunolabeling of the ~35 kDa TGN38/46 protein. Also present is the glycosylated TGN 38/46 protein at ~97 kDa.
TGN38, also known as TGN46, is a type 1 integral membrane protein which predominantly localizes to the trans-Golgi network (TGN), and rapidly cycles to and from the cell surface. The cytosolic domain of TGN38/46 is involved in the reversible recruitment to the membrane with other cytosolic proteins for vesicle formation, while the luminal domain is involved in maintaining the morphology of the TGN (Banting, G., Ponnambalam, S., 1997). The cytosolic domain of TGN38/46 forms a complex with rab6, a small GTP-binding protein, and p62 where vesicle formation occurs at the exit sites of the TGN (Jones, S.M., et al, 1993). TGN38 is widely used as a reliable Golgi marker.
Antigen Affinity Purified from Pooled Serum
35, 97 kDa
Synthetic peptide from the C-terminus region of the rat TGN38/46 protein, conjugated to keyhole limpet hemocyanin (KLH).
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Specific for endogenous levels of the ~35 kDa TGN38 protein. Additionally, a ~97 kDa band representing glycosylated TGN38 protein may be seen in rodent species.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
TGN 46 antibody, TGN 51 antibody, TGN38 antibody, TTGN1 antibody, TGN38 homolog antibody, TGN38B antibody, TGN46 antibody, TGN48 antibody, TGN51 antibody, TGOLN2 antibody, TGON2_HUMAN antibody, Trans Golgi network integral membrane protein 2 antibody, Trans golgi network protein 2 antibody, Trans Golgi network protein TGN51 antibody, Trans-Golgi network integral membrane protein 2 antibody, Trans-Golgi network protein TGN51 antibody, TTGN2 antibody
UniProt (Immunogen Species): P19814
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