Anti-Syk (Central region) Antibody (M373)

Name: Anti-Syk (Central region) Antibody
Brand: PhosphoSolutions
SKU: SM3731
Price: 255.0 USD
Availability: InStock

from PhosphoSolutions Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

M373

Applications

Host Species

Mouse

Format

Protein A Purified

Gene Name

SYK

Molecular Weight

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Western blot of adult mouse spleen lysate. The blot was probed with mouse monoclonal anti-Syk (Central region) antibody at 1:250.

Volume: 100 µL

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Target

Syk (Central region)

Target Description

Syk is a member of the family of non-receptor type protein-tyrosine kinases and plays a crucial role in lymphocyte signaling and development. Syk is expressed in all hematopoietic cells and contributes to the signal transduction process by binding to a tyrosine-based activation motif (ITAM) of immune receptors, including Igα, TCRζ, CD3ε, FcεRIβ, and FceRIγ. Upon receptor activation, Syk binds to phosphorylated ITAMs via its two N-terminal SH2 domains, thereby activating Syk and causing tyrosines in Syk to undergo auto-phosphorylation or phosphorylation. These phosphorylated sites can act as binding sites for other signaling molecules or help to regulate enzymatic activity. For example, in mast cells, Syk can activate downstream targets such as phospholipase Cγ1 and VAV. Studies in Syk-/- mast cells identified defects in both the ERK-MAP and JNK-MAP kinase pathways.

Format

Protein A Purified

Clonality

Monoclonal

Clone

M373

Isotype

IgG1

Applications

Host Species

Mouse

Gene Name

SYK

Molecular Weight

Antigen

Clone M373 was generated from a sequence corresponding to amino acids in the central region of human Syk. This sequence has high homology to mouse and rat Syk.

Species Reactivity

Human, Mouse, Rat

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Dilution Ranges

WB: 1:250

Conjugate

Unconjugated

Specificity

This antibody detects a 72 kDa* protein corresponding to the molecular mass of Syk on SDS-PAGE immunoblots of adult mouse spleen.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk

UniProt Details

UniProt (Human): P43405
UniProt (Immunogen Species): P43405

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Anti-Syk (Central region) Antibody (M373)

Anti-Syk (Central region) Antibody
SKU: SM3731

Bulk Order Anti-Syk (Central region) Antibody

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