Anti-SHP2 (N-terminal region) Antibody (M163)

Name: Anti-SHP2 (N-terminal region) Antibody
Brand: PhosphoSolutions
SKU: SM1631
Price: 255.0 USD
Availability: InStock

from PhosphoSolutions

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

M163

Applications

Host Species

Mouse

Format

Protein A Purified

Gene Name

PTPN11

Molecular Weight

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Western blot analysis of adult mouse brain. The blot was probed with anti-SHP2 (N-terminal) antibody at 1:250 (lane 1), 1:500 (lane 2), 1:1000 (lane 3), and 1:2000 (lane 4).

Volume: 100 µL

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Product Details

Target

SHP2 (N-terminal region)

Target Description

SHP2 (PTP1D, SH-PTP2, or Syp) is a widely expressed protein-tyrosine phosphatase (PTP) that maintains phosphotyrosine homeostasis during growth factor, cytokine, hormone and antigen receptor signaling. This phosphatase contains two N-terminal SH2 domains and a C-terminal phosphatase domain. SHP2 associates with EGF and PDGF growth factor receptors and is activated after stimulation of these receptors. Activation of SHP-2 and its association with Gab1 is critical for sustained ERK activation downstream of both growth factor and cytokine receptors. In addition to its role in Gab1-mediated Erk activation, SHP-2 attenuates EGF-dependent PI3 kinase activation by dephosphorylating Gab1 p85 binding sites. Thus, SHP2 is critical for maintaining phosphotyrosine homeostasis in many cell signaling pathways

Format

Protein A Purified

Clonality

Monoclonal

Clone

M163

Isotype

IgG1

Applications

Host Species

Mouse

Gene Name

PTPN11

Molecular Weight

Antigen

Clone (M163) was generated from a recombinant protein containing amino acids in the N-terminal region of human SHP2. This sequence is highly conserved in rat and mouse SHP2.

Species Reactivity

Human, Mouse, Rat

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Dilution Ranges

WB: 1:1000

Conjugate

Unconjugated

Specificity

The antibody detects a 72 kDa* protein in human A431 and Jurkat cells, and mouse brain. This antibody does not cross-react with SHP1.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

PTP1D, SHPTP2, Syp

UniProt Details

UniProt (Human): Q06124
UniProt (Immunogen Species): Q06124

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Anti-SHP2 (N-terminal region) Antibody (M163)

Anti-SHP2 (N-terminal region) Antibody
SKU: SM1631

Bulk Order Anti-SHP2 (N-terminal region) Antibody

Product Details

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Anti-SHP2 (N-terminal region) Antibody (M163)

Anti-SHP2 (N-terminal region) Antibody SKU: SM1631

Bulk Order Anti-SHP2 (N-terminal region) Antibody

Product Details

Anti-SHP2 (N-terminal region) Antibody
SKU: SM1631