Anti-SARM1 Antibody

Name: Anti-SARM1 Antibody
Brand: PhosphoSolutions
SKU: 1901-SARM1
Price: 430.0 USD
Availability: InStock

Our Anti-SARM1 Antibody primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, and rat SARM1 and is antigen affinity purified from pooled serum. It is great for use in WB, ICC.

Western blot of HeLa cell lysate showing specific immunolabeling of the ~79 kDa SARM1 protein.

Immunofluorescence of transfected COS-7 cells specifically labeling the positive SARM1 cells using our anti-SARM1 antibody (1:50, red) and anti-FLAG antibody (green). The yellow color results from the overlap of cells labeled with both antibodies. DNA is labeled with DAPI (blue).

Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Rabbit

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from PhosphoSolutions Datasheet

Trial Size

Pooled Serum

SKU: 1901-SARM1

Size: 100 uL

Variant

Price:

$430

Quantity:

Product Details

Target

SARM1

Target Description

NAD(+) hydrolase sterile alpha and TIR motif-containing protein 1 (SARM1), is the fifth member of the Toll/Il-1 Receptor (TIR) domain protein family. The highly conserved 724 amino acid protein is predominantly expressed in the brain, kidney and liver (Mink, M., et al 2001). Furthermore, SARM1 is enriched in the cytoplasm, mitchondria, and the axons, dendrites, and synapses of neurons (Panneerselvam, P., et al, 2012). SARM1 plays a key role in axonal degeneration by catalyzing the cleavage of NAD+ into ADPR, cADPR, and nicotinamide in response to injury triggering Wallerian degeneration (Gerdts, J. et al 2015). SARM1 has also been shown to activate neuronal cell death in response to stress (Peng, J. et al. 2010).

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

ICC, WB

Host Species

Rabbit

Gene Name

SARM1

Molecular Weight

79 kDa

Antigen

Full length recombinant human SARM1 protein.

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2922825

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by affinity purification using a column to which the recombinant protein antigen was coupled.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
ICC: 1:50

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~79 kDa SARM1 protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

FLJ36296 antibody, KIAA0524 antibody, MyD88-5 antibody, SAM and ARM-containing protein antibody, SAM domain-containing protein 2 antibody, SAMD2 antibody, SARM 1 antibody, SARM1 antibody, SARM1_HUMAN antibody, Sterile alpha and Armadillo repeat protein antibody, sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila antibody, sterile alpha and HEAT/Armadillo motifs-containing protein antibody, sterile alpha and TIR motif containing 1 antibody, Sterile alpha and TIR motif-containing protein 1 antibody, Sterile alpha and TIR motifs-containing protein 1 antibody, Sterile alpha motif domain-containing protein 2 antibody, Tir-1 homolog antibody

UniProt Details

UniProt (Human): Q6SZW1
UniProt (Immunogen Species): Q6SZW1

NCBI Gene ID

23098

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Product Specific Protocols

Western Blot Protocol: Download

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Anti-SARM1 Antibody

Our Anti-SARM1 Antibody primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, and rat SARM1 and is antigen affinity purified from pooled serum. It is great for use in WB, ICC.

SKU: 1901-SARM1

Product Details

Bulk Order Anti-SARM1 Antibody

Product Specific Protocols

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