Anti-Retinoid X Receptor, γ-Isotype Antibody (1373)
Our Anti-Retinoid X Receptor, γ-Isotype primary antibody from PhosphoSolutions is mouse monoclonal. It detects human and rat Retinoid X Receptor, γ-Isotype and is Protein G purified. It is great for use in WB.
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~48 kDa RXR-γ isotype.
Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXRα, β and γ) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
Protein G Purified
Monoclonal
1373
IgG1
WB
Mouse
RXRG
48 kDa
Synthetic peptide corresponding to amino acid residues from the hinge region of human retinoid X receptor, γ-isotype, conjugated to keyhole limpet hemocyanin (KLH).
Human, Rat
Bovine, Mouse, Non-Human Primate
AB_2492231
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Liquid
Prepared from tissue culture supernatant by ammonium sulfate precipitation followed by purification on a Protein G column.
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
WB: 1:1000
WB Brain: 1:1000
Unconjugated
Specific for endogenous levels of the ~48 kDa RXR-γ isotype.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
MGC109416 antibody, NR2B3 antibody, Nuclear receptor subfamily 2 group B member 3 antibody, OTTHUMP00000060418 antibody, Retanoic X receptor gamma antibody, Retinoic acid receptor RXR gamma antibody, Retinoic acid receptor RXR-gamma antibody, Retinoid X receptor gamma antibody, RXR G antibody, RXR gamma antibody, RXRC antibody, Rxrg antibody, RXRG_HUMAN antibody, RXRgamma antibody
Abu, J., Batuwangala, M., Herbert, K. and Symonds, P., 2005. Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. The Lancet Oncology, 6(9), pp.712-720. PMID: 16129372
Joshi, S., Guleria, R., Pan, J., DiPette, D. and Singh, U.S., 2006. Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene, 25(2), p.240. PMID: 16158052
Lane, M.A. and Bailey, S.J., 2005. Role of retinoid signalling in the adult brain. Progress in Neurobiology, 75(4), pp.275-293. PMID: 15882777
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