Anti-PUMA Antibody

Name: Anti-PUMA Antibody
Brand: PhosphoSolutions
SKU: 24277
Price: 430.0 USD
Availability: InStock

Our PUMA rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human PUMA and is antigen affinity purified. It is great for use in WB.

Western Blot of transfected U20S cell lysate showing specific immunolabeling of PUMA. This antibody detects alpha as well as beta forms of PUMA.

Species Reactivity

Human

Applications

Host Species

Rabbit

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SKU: 24277

Product Details

Target

PUMA

Target Description

A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

Host Species

Rabbit

Gene Name

BBC3

Antigen

Synthetic peptide corresponding to amino acids from a sequence found in the exon-3-encoded region in the human PUMA-a and PUMA-b forms of the protein.

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with a sequence found in the exon-3-encoded region in the human PUMA-a and PUMA-b forms of the protein. Recognizes both forms of the protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

BBC3, Bcl-2-binding component 3, isoforms 1/2, JFY1, p53 up-regulated modulator of apoptosis

UniProt Details

UniProt (Human): Q9BXH1
UniProt (Immunogen Species): Q9BXH1

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Anti-PUMA Antibody

SKU: 24277

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