Anti-Parkin Antibody

Name: Anti-Parkin Antibody
Brand: PhosphoSolutions
SKU: 24552
Price: 415.0 USD
Availability: InStock

from PhosphoSolutions

Our Parkin rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Parkin and is antigen affinity purified. It is great for use in WB.

Product Type

Primary Antibody

Species Reactivity

Human

Applications

Host Species

Rabbit

Format

Antigen Affinity Purified

Gene Name

PRKN

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Title: 100 µL

Variant

Price:

$415

Quantity:

Bulk Order Anti-Parkin Antibody

Product Details

Target

Parkin

Target Description

Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

Host Species

Rabbit

Gene Name

PRKN

Antigen

Synthetic peptide corresponding to amino acids from the N-terminal region of human Parkin protein.

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N-terminal region of the 52 kDa human Parkin protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

PRKN, E3 ubiquitin-protein ligase parkin, PARK2

UniProt Details

UniProt (Human): O60260
UniProt (Immunogen Species): O60260

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Anti-Parkin Antibody

Our Parkin rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Parkin and is antigen affinity purified. It is great for use in WB.