The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms' tumor. Par-4 (for prostate apoptosis response) is a WT1-interacting protein that also functions as a transcriptional repressor. Par-4 contains a putative leucine zipper domain and is specifically upregulated during apoptosis of prostate cells.
Antigen Affinity Purified
Synthetic peptide corresponding to amino acids from the N-terminal region of human PAR4 protein
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
PBS + 0.02% NaN3
WB Brain: 1:500-1:1000
Reacts with the N-terminal region of human PAR4 protein
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.