Anti-Pan-Neurofascin (Extracellular) Antibody (A12/18)

Name: Anti-Pan-Neurofascin (Extracellular) Antibody
Brand: NeuroMab
SKU: 75-172
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Nfasc

Molecular Weight

155, 186 kDa

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$immunoblot on crude membrane fractions from whole mouse (MBM) and rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with A12/18 (left) and N52A/42 (right) TC supe.$

immunoblot on crude membrane fractions from whole mouse (MBM) and rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with A12/18 (left) and N52A/42 (right) TC supe.

Product Details

Target

Pan-Neurofascin (extracellular)

Target Description

Neurofascin is encoded by the gene NFASC. Two major isoforms of NeuroFascin are expressed as a result of alternative splicing, NF186 and NF155. These proteins are expressed in the central nervous system. In brain, NF186 is expressed at Nodes of Ranvier andNF155 is expressed in unmyelinated axons. Neuofascin plays a role in cell adhesion and is thought to be involved in processes such as neurite extension, synaptogenesis and myelination. Diseases associated with this gene include Demyelinating Polyneuropathy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

A12/18

Isotype

IgG2a

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Nfasc

Molecular Weight

155, 186 kDa

Antigen

Lipid raft fractions isolated from adult rat brain. Target identified as Neurofascin by: - binding to NF-186-tranfected COS cells- recognition of NF155 and NF186 but not other highly related L1 CAMs like NrCAM- immunoprecipitation of NF155 and NF186 and confirmation by mass spectrometry - loss of immunostaining against NF186-shRNA knockdown samples Rat: amino acids 25-1110 (extracellular domain common to NF155 and NF186); Mouse: 98% identity (1074/1086 amino acids identical); Human: 79% identity (955/1195 amino acids identical); This NeuroMab antibody is considered "Restricted" and is therefore not available for commercial re-distribution on a for-profit basis.

Species Reactivity

Human, Rat

Antibody Registry ID

AB_2282826

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Neurofascin NF-155 NF-186

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Anti-Pan-Neurofascin (Extracellular) Antibody (A12/18)

Anti-Pan-Neurofascin (Extracellular) Antibody
SKU: 75-172

Product Details

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Anti-Pan-Neurofascin (Extracellular) Antibody (A12/18)

Anti-Pan-Neurofascin (Extracellular) Antibody SKU: 75-172

Product Details

Anti-Pan-Neurofascin (Extracellular) Antibody
SKU: 75-172