Anti-Musashi 1 Antibody

Name: Anti-Musashi 1 Antibody
Brand: PhosphoSolutions
SKU: 24517
Price: 430.0 USD
Availability: InStock

Our Musashi 1 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Musashi 1 and is antigen affinity purified. It is great for use in WB.

Immunohistochemistry of the ventricular zone of E14.5 mouse medulla showing specific staining of Musashi-1. Image taken at 200x magnification. The sections were 4% PFA fixed, paraffin-embedded and cut at 5 microns.

Immunocytochemistry of human neural rosettes showing specific staining of Musashi-1 in green. Nuclei are counterstained blue (DAPI). Cells were fixed with 4 percent PFA. No antigen retrieval was done.

Western Blot of 10 ug of rat neural stem cell lysate (lane 1) and normal human brain lysate (lane 2) showing specific immunolabeling of Musashi-1.

Immunohistochemistry of the ventricular zone of E14.5 mouse medulla showing specific staining of Musashi-1. Image taken at 200x magnification. The sections were 4% PFA fixed, paraffin-embedded and cut at 5 microns.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Rabbit

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SKU: 24517

Product Details

Target

Musashi 1

Target Description

Musashi 1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi 1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson's. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer's disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders. Musashi 1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ICC, IHC, WB

Host Species

Rabbit

Gene Name

MSI1

Antigen

Synthetic peptide corresponding to amino acids from the N-terminal region of the human, mouse and rat Musashi 1 protein

Species Reactivity

Human, Mouse, Rat

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N-terminal region of the human, mouse and rat Musashi 1 protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

MSI1, RNA-binding protein Musashi homolog 1

UniProt Details

UniProt (Human): O43347
UniProt (Immunogen Species): O43347

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Anti-Musashi 1 Antibody

SKU: 24517

Product Details

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