Our Anti-Microtubule Associated Protein 2 C/D (MAP2C/D) primary antibody from PhosphoSolutions is mouse monoclonal. It detects bovine, human, mouse, and rat Microtubule Associated Protein 2 C/D (MAP2C/D) and is Protein G purified. It is great for use in WB, IHC, ICC.
Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~70 kDa MAP2C/D proteins and the ~280 kDa MAP2A/B proteins.
Anti-Microtubule Associated Protein 2 C/D (MAP2C/D) Antibody
Microtubule Associated Protein 2 C/D (MAP2C/D)
Microtubules are 25nm diameter protein rods found in most kinds of eukaryotic cells. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein τ (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5 (Kindler & Gardner 1994). MAP2 is made up of two ~280 kDa bands referred to as MAP2a and MAP2b. A third lower molecular weight form, MAP2C and MAP2D, corresponds to a pair of protein bands running at ~70 kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide sequences, which are very similar to those found in the related microtubule binding protein τ (tau). MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. MAP2C and MAP2D are expressed earlier in development than the MAP2a and MAP2b isoforms, so that this antibody is a more useful marker of neuronal development. MAP2 has been recently shown to be the specific receptor for the neurosteroid pregnenolone (FontaineLenore V. et al., 2006).
Protein G Purified
ICC, IHC, WB
Full length recombinant human MAP2D protein.
Bovine, Human, Mouse, Rat
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Kindler S, Gardner CC (1994) Four repeat MAP2 isoforms in human and rat brain. Brain Res Mol Brain Res. 26(1-2):218-224.PMID: 7854050
Fontaine-Lenore V, Chambraud B, Fellous A, David S, Duchossoy Y, Baulieu EE, Robel P (2006) Microtubule-associated protein 2 (MAP2) is a neurosteroid. Proc Natl Acad Sci USA 103(12):4711-6. PMID: 16537405
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