Anti-MeCP2 Antibody

Name: Anti-MeCP2 Antibody
Brand: PhosphoSolutions
SKU: 1207-MeCP2
Price: 415.0 USD
Availability: InStock

from PhosphoSolutions Datasheet

Trial Size

Our Anti-MeCP2 Antibody primary antibody from PhosphoSolutions is chicken polyclonal. It detects human, mouse, non-human primate, and rat MeCP2 and is total IgY fraction. It is great for use in WB, IHC.

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Applications

IHC, WB

Host Species

Chicken

Format

Total IgY fraction

Gene Name

MECP2

Molecular Weight

75 kDa

Go to Full Product Details

Western blot of mouse whole brain lysate showing specific immunolabeling of the MeCP2 protein at ~75 kDa.

Immunostaining of a section of rat olfactory bulb showing specific labeling of MeCP2 in neuronal nuclei (Cat. No. 1207-MECP2, red, 1:2000) and alpha synuclein (green). The blue is DAPI staining of nuclear DNA.

Volume: 100 µL

Variant

Price:

$415

Quantity:

Bulk Order Anti-MeCP2 Antibody

Product Details

Target

MeCP2

Target Description

MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998). Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999). RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Format

Total IgY fraction

Clonality

Polyclonal

Applications

IHC, WB

Host Species

Chicken

Gene Name

MECP2

Molecular Weight

75 kDa

Antigen

Full length human recombinant MeCP2

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2905462

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 µL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles.

Physical State

Liquid

Production Notes

Total IgY fraction

Buffer

PBS + 5 mM NaN₃

Dilution Ranges

WB: 1:20,000
WB Brain: 1:20,000
IHC: 1:1000-1:2000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the MeCP2 protein. Due to usually high charge, the protein runs at ~75 kDa in SDS-PAGE of mouse brain lysates.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

AUTSX 3 antibody, AUTSX3 antibody, DKFZp686A24160 antibody, Mbd 5 antibody, Mbd5 antibody, MECP 2 antibody, MeCP 2 protein antibody, MeCP-2 protein antibody, Mecp2 antibody, MECP2_HUMAN antibody, Methyl CpG binding protein 2 (Rett syndrome) antibody, Methyl CpG binding protein 2 antibody, Methyl-CpG-binding protein 2 antibody, MRX 16 antibody, MRX 79 antibody, MRX16 antibody, MRX79 antibody, MRXS 13 antibody, MRXS13 antibody, MRXSL antibody, PPMX antibody, RS antibody, RTS antibody, RTT antibody, WBP 10 antibody, WBP10 antibody

UniProt Details

UniProt (Human): P51608
UniProt (Immunogen Species): P51608

NCBI Gene ID

4204

Product Specific Protocols

Western Blot Protocol: Download

Recover password

Create my account

Anti-MeCP2 Antibody

Our Anti-MeCP2 Antibody primary antibody from PhosphoSolutions is chicken polyclonal. It detects human, mouse, non-human primate, and rat MeCP2 and is total IgY fraction. It is great for use in WB, IHC.