Anti-Integrin β3 (Extracellular region) Antibody (M581)

Name: Anti-Integrin β3 (Extracellular region) Antibody
Brand: PhosphoSolutions
SKU: IM5811
Price: 329.0 USD
Availability: InStock

Our Integrin β3 (Extracellular region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Integrin β3 (Extracellular region) and is Protein A purified. It is great for use in WB, ICC.

Western blot analysis of human umbilical vein endothelial cells (HUVEC). The blots were probed with mouse monoclonal anti-integrin β3 (IM5811) at 1:250 (lane 1) and 1:1000 (lane 2).

Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

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SKU: IM5811

Product Details

Target

Integrin β3 (Extracellular region)

Target Description

Integrins are cell adhesion molecules that can mediate bidirectional transfer of signals across the plasma membrane. The cytoplasmic domains of integrin family members interact with components of the signal transduction apparatus within cells. Integrin receptors contain noncovalently associated α and β subunits that consist of a large extracellular region (the ligand-binding domain), a short transmembrane region, and a cytoplasmic domain of varying length. In mammals, at least 17 α subunits and 8 β subunits have been identified and these proteins can heterodimerize to form at least 22 different receptors. The integrin β2 subunit associates with integrin αL to form a receptor for ICAM family members. Integrin β2/αL is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

Format

Protein A Purified

Clonality

Monoclonal

Clone

M581

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

ITGB3

Molecular Weight

100

Antigen

Clone M581 was generated from a recombinant protein containing amino acid residues in the extracellular region of human Integrin β3. This sequence has high homology with rat and mouse Integrin β3, and has low homology to other integrin family members.

Species Reactivity

Human, Mouse, Rat

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Dilution Ranges

WB: 1:500
ICC: 1:50

Conjugate

Unconjugated

Specificity

This antibody detects a 100kDa* protein corresponding to the molecular mass of Integrin β3 on SDS-PAGE immunoblots of human platelets and endothelial cells (HUVEC).

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A

UniProt Details

UniProt (Human): P05106
UniProt (Immunogen Species): P05106

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Anti-Integrin β3 (Extracellular region) Antibody (M581)

SKU: IM5811

Product Details

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