Anti-GluN1/NR1 Glutamate Receptor Antibody (N308/48)

Detect GluN1/NR1 Glutamate Receptor with this antibody validated for IHC, WB, ICC.

Primary Antibody
Human, Mouse, Rat
Grin1 Nmdar1
105 kDa

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Anti-GluN1/NR1 Glutamate Receptor Antibody
SKU: 75-272

Volume: 100 µL
Sale price$361

Bulk Order Anti-GluN1/NR1 Glutamate Receptor Antibody

Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
2774671210 µg/mLBagasrawala, I., et al. 2016. N-Methyl D-Aspartate Receptor Antagonist Kynurenic Acid Affects Human Cortical Development. Frontiers in Neuroscience, 435.
Immunocytochemistry: Mouse
PMID Dilution Publication
349629571:200Lee, G.S., et al. 2021. 14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons. PloS One, e0261791.
34781056not listedWang, B., et al. 2021. Lipid bilayers regulate allosteric signal of NMDA receptor GluN1 C-terminal domain. Biochemical and biophysical research communications, 15-21.
336896781:200Fang, H., et al. 2021. An optimized CRISPR/Cas9 approach for precise genome editing in neurons. eLife, e65202.
31554851not listedPlumbly, W., et al. 2019. L-type voltage-gated calcium channel regulation of in vitro human cortical neuronal networks. Scientific Reports, 13810.
303337301:1000Zhou, L., et al. 2018. The C-terminus of NMDAR GluN1-1a subunit translocates to nucleus and regulates synaptic function. Frontiers in Cellular Neuroscience, 334.
297604091:500Ma, K., et al. 2018. Histone deacetylase inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism. Neuropsychopharmacology, 1779-1788.
25644714not listedDiBattista, A.M., et al. 2015. Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.. Biochimica et Biophysica Acta, 904-917.
240324331:100Wang, X., et al. 2013. Activation of α7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses. Journal of Neurochemistry, 632-643.
Immunocytochemistry: Rat
PMID Dilution Publication
32604880not listedGarcía, F., et al. 2020. Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation. Marine Drugs, 335.
26675527not listedLee, N.J., et al. 2016. Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1-Ras dependent pathway.. Biochimica et Biophysica Acta, 284-295.
240894841:500Duffney, L.J., et al. 2013. Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism.. The Journal of Neuroscience, 15767-15778.
24012668not listedYI, S., et al. 2013. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.. Biochemical and Biophysical Research Communications, .
237742771:500Cheng, J., et al. 2013. SNARE proteins are essential in the potentiation of NMDA receptors by group II metabotropic glutamate receptors.. The Journal of Physiology, 3935-3947.
Immunohistochemistry: Mouse
PMID Dilution Publication
300544481:500Risher, W.C., et al. 2018. Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. Journal of Cell Biology, 3747-3765.
263170101:300Fourie, C., et al. 2014. Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington''s Disease and Parkinson''s Disease Human Brains.. Journal of Neurodegenerative Diseases, 938530.
253527481:500de Andrade, G.B., et al. 2014. Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina.. Molecular Vision, 1422-1433.
243367191:1000Gunn, B.G., et al. 2013. Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response.. The Journal of Neuroscience, 19534-19554.
232337841:500DeParis, S.W., et al. 2012. Intrinsically photosensitive retinal ganglion cells are resistant to N-methyl-D-aspartic acid excitotoxicity.. Molecular Vision, 2814-2827.
Immunohistochemistry: Rat
PMID Dilution Publication
269304431:2000Rambousek, L., et al. 2016. Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits. Neuropharmacology, 594-606.
258223375 µg/mLBalsara, R., et al. 2015. Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke.. PLoS One, e0122840.
Western Blot: Human
PMID Dilution Publication
30355732not listedZhou, J.J., et al. 2018. The α2δ-1–NMDA receptor coupling is essential for corticostriatal long-term potentiation and is involved in learning and memory. Journal of Biological Chemistry, 19354-19364.
2774671210 µg/mLBagasrawala, I., et al. 2016. N-Methyl D-Aspartate Receptor Antagonist Kynurenic Acid Affects Human Cortical Development. Frontiers in Neuroscience, 435.
256351401:5000Xu, M., et al. 2015. Cysteine Substitution of Transmembrane Domain Amino Acids Alters the Ethanol Inhibition of GluN1/GluN2A N-Methyl-d-Aspartate Receptors. The Journal of Pharmacology and Experimental Therapeutics, 91-101.
253160861:300Maraschi, A.M., et al. 2014. Parkin regulates kainate receptors by interacting with the GluK2 subunit.. Nature Communications, 5182.
Western Blot: Mouse
PMID Dilution Publication
364217051:500-1:1500Maisterrena, A., et al. 2022. The State Of The Dopaminergic And Glutamatergic Systems In The Valproic Acid Mouse Model Of Autism Spectrum Disorder. Biomolecules, .
357898511:1000Huo, Y., et al. 2022. Prkn Knockout Mice Show Autistic-like Behaviors and Aberrant Synapse Formation. iScience, 104573.
349629571:1000Lee, G.S., et al. 2021. 14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons. PloS One, e0261791.
335421891:500Zhang, F., et al. 2021. Synergistic inhibition of histone modifiers produces therapeutic effects in adult Shank3-deficient mice. Translational Psychiatry, 99.
33402706not listedMossa, A., et al. 2021. Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice. Molecular Psychiatry, 1928–1944.
332984401:1000Cao, Q., et al. 2020. Targeting histone K4 trimethylation fortreatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease. Science Advances, eabc8096.
33229412not listedPandian, S., et al. 2020. Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses. eNeuro, ENEURO.0284-20.2020.
331584441:1000Espinoza, S., et al. 2020. Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG. BMC Biology, 164.
312007421:1000Micci, M.A., et al. 2019. Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes. Molecular Neurodegeneration, 25.
297068651:1000Khlghatyan, J., et al. 2018. Mental illnesses-associated Fxr1 and its negative regulator Gsk3β are modulators of anxiety and glutamatergic neurotransmission. Frontiers in Molecular Neuroscience, 119.
290694391:100Shahin, S., et al. 2018. From the cover: 2.45-GHz microwave radiation impairs hippocampal learning and spatial memory: Involvement of local stress mechanism-induced suppression of …. Toxicological Sciences, 349-374.
28215989not listedLi, Q., et al. 2017. Klotho regulates CA1 hippocampal synaptic plasticity. Neuroscience, 123-133.
274757241:500Qin, L., et al. 2016. The ADHD-linked human dopamine D4 receptor variant D4. 7 induces over-suppression of NMDA receptor function in prefrontal cortex. Neurobiology of Disease, 194-203.
27334260not listedHuang, L., et al. 2016. Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Science Translational Medicine, 344ra85.
270986981:10D'Orsi, B., et al. 2016. Bok is not pro-apoptotic but suppresses poly ADP-ribose polymerase-dependent cell death pathways and protects against excitotoxic and seizure-induced neuronal …. The Journal of Neuroscience, 4564-4578.
27066908not listedVingtdeux, V., et al. 2016. CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice. Scientific Reports, 24250.
26714288not listedMoraga-Amaro, R., et al. 2016. Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory.. Neuropharmacology, 222-235.
263069191:200Lv, J.M., et al. 2016. The Noncompetitive AMPAR Antagonist Perampanel Abrogates Brain Endothelial Cell Permeability in Response to Ischemia: Involvement of Claudin-5.. Cellular and Molecular Neurobiology, 745-753.
25644714not listedDiBattista, A.M., et al. 2015. Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.. Biochimica et Biophysica Acta, 904-917.
256321451:10D'Orsi, B., et al. 2015. Bax regulates neuronal Ca2+ homeostasis.. The Journal of Neuroscience, 1706-1722.
254715851:500Warmus, B.A., et al. 2014. Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.. The Journal of Neuroscience, 16482-16495.
254076771:1000Gomez, A.M., et al. 2014. Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4.. eLife, e04287.
253084311:1000Carney, K.E., et al. 2014. Proteomic analysis of gliosomes from mouse brain: identification and investigation of glial membrane proteins.. Journal of Proteome Research, 5918-5927.
25146373not listedYan, Y., et al. 2015. Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching.. Cerebral Cortex, 3487-3501.
240945801:500Deng, Y., et al. 2014. β-amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3.. Neurobiology of Aging, 449-459.
Western Blot: Rat
PMID Dilution Publication
358621681:500Zhou, J.J., et al. 2022. Calcineurin Controls Hypothalamic NMDA Receptor Activity and Sympathetic Outflow. Circulation Research, 345-360.
33593893not listedBuss, E.W., et al. 2021. Cognitive aging is associated with redistribution of synaptic weights in the hippocampus. PNAS, e1921481118.
294875221:1000Uttl, L., et al. 2018. Chronic MK-801 application in adolescence and early adulthood: a spatial working memory deficit in adult Long-Evans rats but no changes in the …. Frontiers in Pharmacology, 42.
271471181:3000Spencer, K.B., et al. 2016. FMRP mediates chronic ethanol‐induced changes in NMDA, Kv4. 2, and KChIP3 expression in the hippocampus. . Alcoholism: Clinical and Experimental Research, 1251-1261.
241030311:500Luo, P., et al. 2013. Downregulation of postsynaptic density-95-interacting regulator of spine morphogenesis reduces glutamate-induced excitotoxicity by differentially regulating glutamate receptors in rat cortical neurons.. The FEBS Journal, 6114-6127.
23486974not listedMurata, Y., et al. 2013. Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.. The Journal of Neuroscience, 5040-5052.

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