Name: Anti-GABAA Receptor ß2 Antibody
Brand: PhosphoSolutions
SKU: 862-GB2C
Price: 415.0 USD
Availability: InStock

Our Anti-GABAA Receptor ß2 primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse and rat GABAA Receptor ß2 and is antigen affinity purified. It is great for use in WB.

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Expected Reactivity

Bovine, Canine, Human, Non-Human Primate

Applications

WB

Host Species

Rabbit

Format

Antigen Affinity Purified

Gene Name

GABRB2

Molecular Weight

55 kDa

Go to Full Product Details

Western blot of 7 µg of rat cerebellar lysate showing specific immunolabeling of the ~55 kDa β2-subunit of the GABAA-R.

Volume: 100 µL

Variant

Price:

$415

Quantity:

Bulk Order Anti-GABAA Receptor ß2 Antibody

Product Details

Target

GABAA Receptor ß2

Target Description

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

WB

Host Species

Rabbit

Gene Name

GABRB2

Molecular Weight

55 kDa

Antigen

Fusion protein from the cytoplasmic loop of the ß2 subunit of rat GABAA receptor.

Species Reactivity

Mouse, Rat

Expected Reactivity

Bovine, Canine, Human, Non-Human Primate

Antibody Registry ID

AB_2492109

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~55 kDa β2-subunit of the GABAA receptor.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

GABA antibody, GABA(A) receptor beta 2 antibody, GABA(A) receptor subunit beta-2 antibody, GABA-A receptor, beta-2 polypeptide antibody, GABRB2 antibody, Gamma aminobutyric acid (GABA) A receptor, beta 2 antibody, Gamma aminobutyric acid A receptor beta 2 antibody, Gamma-aminobutyric acid receptor subunit beta-2 antibody, Gamma-aminobutyric-acid receptor subunit beta-2 antibody, GBRB2_HUMAN antibody

UniProt Details

UniProt (Human): P47870
UniProt (Immunogen Species): P63138

NCBI Gene ID

25451

Product Specific References for Applications and Species

Western Blot: Mouse

Western Blot: Mouse
PMID	Dilution	Publication
26172316	1:1000	Raible, D.J., et al. 2015. JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI. Experimental neurology, 271, pp.445-456.

Product Specific Protocols

Western Blot Protocol: Download

Recover password

Create my account

Anti-GABAA Receptor ß2 Antibody

Our Anti-GABAA Receptor ß2 primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse and rat GABAA Receptor ß2 and is antigen affinity purified. It is great for use in WB.