Our Anti-GABA Transporter (GAT) 2 primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse and rat GABA Transporter (GAT) 2 and is affinity purified. It is great for use in WB, IHC.
Western blot of mouse whole brain lysate showing specific immunolabeling of the ~67 kDa GAT-2 protein.
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999)
Affinity Purified
Polyclonal
IgG
IHC, WB
Rabbit
SLC6A13
67 kDa
Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAT2, conjugated to keyhole limpet hemocyanin (KLH).
Rat
AB_2492120
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Liquid
Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
WB: 1:100-200
WB Brain: 1:100-200
IHC: 1:100-200
Unconjugated
Specific for endogenous levels of the ~82 kDa GAT-2 protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
GABA transport protein antibody, GAT 2 antibody, GAT-2 antibody, GAT2 antibody, GAT3 antibody, S6A13_HUMAN antibody, SLC6A13 antibody, Sodium- and chloride-dependent GABA transporter 2 antibody, Solute carrier family 6 (Neurotransmitter transporter GABA), member 13 antibody, Solute carrier family 6 member 13 antibody
UniProt (Immunogen Species): P31646
171163
Product Specific References for Applications and Species
Johnson, J., et al. 1997. Multiple γ-aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina. The Journal of Comparative Neurology, 375(2), 212.
