Name: Anti-Dopamine ß-Hydroxylase, N-Terminus Antibody
Brand: PhosphoSolutions
SKU: 423-DBHN
Price: 415.0 USD
Availability: InStock

Our Anti-Dopamine ß-Hydroxylase, N-Terminus sheep polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human and non-human primate Dopamine ß-Hydroxylase, N-Terminus and is antigen affinity purified from pooled serum. It is great for use in WB.

Product Type

Primary Antibody

Species Reactivity

Human, Non-Human Primate

Applications

WB

Host Species

Sheep

Format

Antigen Affinity Purified from Pooled Serum

Gene Name

DBH

Molecular Weight

75 kDa

Go to Full Product Details

Western blot of human adrenal medulla lysate showing specific immunolabeling of the ~75 kDa DBH protein.

Volume: 100 µL

Variant

Price:

$415

Quantity:

Bulk Order Anti-Dopamine ß-Hydroxylase, N-Terminus Antibody

Product Details

Target

Dopamine ß-Hydroxylase, N-Terminus

Target Description

DBH catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. DBH antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). The expression of DBH is also elevated during stress (Sabban and Kvetnansky, 2001).

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

WB

Host Species

Sheep

Gene Name

DBH

Molecular Weight

75 kDa

Antigen

Synthetic peptide from the N-terminal region of human dopamine β-hydroxylase (DBH), conjugated to keyhole limpet hemocyanin (KLH).

Species Reactivity

Human, Non-Human Primate

Antibody Registry ID

AB_2492075

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from pooled sheep serum by affinity purification using a column matrix to which the peptide immunogen was coupled.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~75 kDa DBH protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

dbh antibody, DBM antibody, Dopamine beta hydroxylase antibody, Dopamine beta monooxygenase antibody, Dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody, Dopamine beta-monooxygenase antibody, DOPO_HUMAN antibody, OTTHUMP00000022501 antibody, Soluble dopamine beta-hydroxylase antibody

UniProt Details

UniProt (Human): P09172
UniProt (Immunogen Species): P09172

NCBI Gene ID

1621

Product Specific Protocols

Western Blot Protocol: Download

General References

Kish, S.J., Kalasinsky, K.S., Derkach, P., Schmunk, G.A., Guttman, M., Ang, L., Adams, V., Furukawa, Y. and Haycock, J.W., 2001. Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology, 24(5), p.561. PMID: 11282256
Sabban, E.L. and Kvetňanský, R., 2001. Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events. Trends in Neurosciences, 24(2), pp.91-98. PMID: 11164939
Zhu, M.Y., Klimek, V., Dilley, G.E., Haycock, J.W., Stockmeier, C., Overholser, J.C., Meltzer, H.Y. and Ordway, G.A., 1999. Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biological Psychiatry, 46(9), pp.1275-1286. PMID: 10560033

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Anti-Dopamine ß-Hydroxylase, N-Terminus Antibody

Our Anti-Dopamine ß-Hydroxylase, N-Terminus sheep polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human and non-human primate Dopamine ß-Hydroxylase, N-Terminus and is antigen affinity purified from pooled serum. It is great for use in WB.