Anti-Atrogin-1 Antibody

Name: Anti-Atrogin-1 Antibody
Brand: PhosphoSolutions
SKU: AP2041
Price: 309.0 USD
Availability: InStock

from PhosphoSolutions

94 Citations

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Applications

IHC, WB

Host Species

Rabbit

Format

Antigen Affinity Purified

Gene Name

Fbxo32

Molecular Weight

Go to Full Product Details

Western blot image of mouse gastrocnemius (lanes 1 & 3) and mouse diaphragm tissue lysate (lanes 2 & 4). The blot was probed with anti-Atrogin-1 (AP2041; lanes 1-4) in the presence (lanes 3 & 4) or absence (lanes 1 & 2) of Atrogin-1 peptide (AX2045).

Formalin fixed, citric acid treated paraffin sections of E16 mouse skeletal muscle. Sections were probed with anti-Atrogin-1 (AP2041) then anti-Rabbit:HRP before detection using DAB. (Images provided by Carl Hobbs and Dr. Pat Doherty at Wolfson Centre for Age-Related Diseases, King's College London).

Western blot analysis of MuRF1 (cat. MP3401), Atrogin-1 (cat. AP2041), FoxO3a, p-AKT (Ser473), and total AKT in the soleus muscle of control, HU, and HU+TUDCA mice. Image from publication CC-BY-4.0. PMID: 37525907

Western blotting analysis of the expression of Atrogin-1 (cat. AP2041, 1:1000) and MuRF1 (cat. MP3401, 1:1000) proteins in the soleus muscles after HS. Image from publication CC-BY-4.0. PMID: 37344807

Western blot showing MuRF-1( cat MP3401, 1:500) and atrogin-1 (cat. AP2041), 1:500) levels in C2C12 myoblasts differentiated for 4–5 days were incubated with 200 μM UDCA for 72 h. GAPDH was used as a loading control. Image from publication CC-BY-4.0. PMID: 37237400

The individual and combined effect of quercetin (Q) and low dose (LL) or high dose (HL) of leucine on relative protein expression of p-FoxO1/FoxO1, Atrogin-1 (cat. AP2041), and MuRF1 (cat. MP3401) in the gastrocnemius muscle in BALB/c mice exposed to cisplatin (CDDP). Image from publication CC-BY-4.0. PMID: 37699022

Representative Western blots for Atrogin-1 (cat. AP2041, 1:1000) in rat ASM cells that were infected for 24 h with Ad-GFP, Ad-Smad3, Ad-FoxO3, or Ad-Smad3/Ad-FoxO3. Image from publication CC-BY-4.0. PMID: 37693008

Western blot image of mouse gastrocnemius (lanes 1 & 3) and mouse diaphragm tissue lysate (lanes 2 & 4). The blot was probed with anti-Atrogin-1 (AP2041; lanes 1-4) in the presence (lanes 3 & 4) or absence (lanes 1 & 2) of Atrogin-1 peptide (AX2045).

Volume: 100 µL

Variant

Price:

$309

Quantity:

Bulk Order Anti-Atrogin-1 Antibody

Product Details

Target

Atrogin-1

Target Description

Atrogin-1/Muscle Atrophy F-box (MAFbx) is an E3 ubiquitin ligase that mediates proteolysis events that occur during muscle atrophy. This ATP-dependent ubiquitin-mediated proteolysis occurs in response to a variety of catabolic states in muscle. Atrogin is expressed in heart and skeletal muscle, and is upregulated during muscle atrophy. In addition, Atrogin expression increases in C2C12 myotubes after stimulation with cytokines. Atrogin is thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Atrogin interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD. Mice deficient in Atrogin are resistant to muscle atrophy.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Rabbit

Gene Name

Fbxo32

Molecular Weight

Antigen

A synthetic peptide (coupled to carrier protein) corresponding to amino acids from the N-terminal region of mouse Atrogin. This sequence is highly homologous to human and rat Atrogin (F-box only protein 32).

Species Reactivity

Human, Mouse, Rat

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Dilution Ranges

WB: 1:1000
IHC: 1:100

Conjugate

Unconjugated

Specificity

This antibody detects a 41 kDa* protein corresponding to the apparent molecular mass of Atrogin on SDS-PAGE immunoblots of mouse muscle tissue lysates. Similar results were seen in C2C12 cell lysate and the band observed in western blot is specifically blocked by Atrogin-1 peptide (AX2045).

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

MAFbx, FBX32, Atrogin

UniProt Details

UniProt (Human): Q969P5
UniProt (Immunogen Species): Q9CPU7

Product Specific References for Applications and Species

Immunocytochemistry: Mouse
Immunohistochemistry: Human | Mouse
Western Blot: Goat | Human | Mouse | Rat | Swine
Additional Publications: Unspecified

Immunocytochemistry: Mouse
PMID	Dilution	Publication
30922397	not listed	Liu, D, et al. 2019. IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway. Skeletal muscle, 8.

Immunohistochemistry: Human
PMID	Dilution	Publication
32173683	not listed	Esposito, P, et al. 2020. Myostatin in the Arterial Wall of Patients with End-Stage Renal Disease. Journal of atherosclerosis and thrombosis, 1039-1052.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
28762162	1:1000	Sakai, H, et al. 2017. Effect of acute treadmill exercise on cisplatin-induced muscle atrophy in the mouse. Pflügers Archiv : European journal of physiology, 1495-1505.
28286533	1:200	Zhang, Y, et al. 2017. Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1. Evidence-based complementary and alternative medicine : eCAM, 6268378.

Western Blot: Goat
PMID	Dilution	Publication
36909853	1:700	Kang, J., et al. 2023. Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of …. Food Science of Aninal Resources, 359-373.

Western Blot: Human
PMID	Dilution	Publication
36980729	1:1000	Saroul, N., et al. 2023. Conditioned Media from Head and Neck Cancer Cell Lines and Serum Samples from Head and Neck Cancer Patients Drive Catabolic Pathways in Cultured …. Cancers, 1843.
35606155	1:1000	Brook, M.S., et al. 2022. Declines in muscle protein synthesis account for short‐term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown. Journal of Cachexia, Sarcopenia and Muscle, 2005-2016.
35176309	1:1000	Shi, X., et al. 2022. Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2–AKT–TGF-β Signaling Axis in Pancreatic Cancer. Gatroenterology, 2004-2017.
34984449	not listed	Dalle, S., et al. 2022. Preliminary evidence of differential expression of myogenic and stress factors in skeletal muscle of older adults with low muscle strength. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 1121-1129.
34857226	1:1000	Brook, MS, et al. 2021. Omega-3 supplementation during unilateral resistance exercise training in older women: A within subject and double-blind placebo-controlled trial. Clinical nutrition ESPEN, 394-404.
34395422	1:1000	Halle, JL, et al. 2021. The Effect of Mechanical Stretch on Myotube Growth Suppression by Colon-26 Tumor-Derived Factors. Frontiers in cell and developmental biology, 690452.
34060253	not listed	Blackwell, J.E.M., et al. 2021. The physiological impact of high‐intensity interval training in octogenarians with comorbidities. Journal of Cachexia, Sarcopenia and Muscle, 866-879.
33804338	not listed	Kim, R, et al. 2021. BST204 Protects Dexamethasone-Induced Myotube Atrophy through the Upregulation of Myotube Formation and Mitochondrial Function. International journal of environmental research and public health, 2367.
32050585	1:500	Aravena, J, et al. 2020. Angiotensin (1-7) Decreases Myostatin-Induced NF-κB Signaling and Skeletal Muscle Atrophy. International journal of molecular sciences, 1167.
31568675	not listed	Gharahdaghi, N, et al. 2019. Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men. Journal of cachexia, sarcopenia and muscle, 1276-1294.
31518665	not listed	Moro, T, et al. 2019. Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults. Experimental gerontology, 110723.
31123725	not listed	Brightwell, C, et al. 2019. Moderate-intensity aerobic exercise improves skeletal muscle quality in older adults. Translational sports medicine, 109-119.
30928279	not listed	Park, YM, et al. 2019. Acute estradiol treatment reduces skeletal muscle protein breakdown markers in early- but not late-postmenopausal women. Steroids, 43-49.
30342032	not listed	Yang, J, et al. 2019. ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells. Gastroenterology, 722-734.

Western Blot: Mouse
PMID	Dilution	Publication
37130808	1:1000	Martin, R.A., et al. 2023. The Pathophysiology of COVID-19 and SARS-CoV-2 Infection: An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease. American Journal of Physiology. Lung Cellular and Molecular Physiology, L870-L878.
36980729	1:1000	Saroul, N., et al. 2023. Conditioned Media from Head and Neck Cancer Cell Lines and Serum Samples from Head and Neck Cancer Patients Drive Catabolic Pathways in Cultured …. Cancers, 1843.
36536512	1:1000	Raymond‐Pope, C.J., et al. 2023. Restricted physical activity after volumetric muscle loss alters whole‐body and local muscle metabolism. The Journal of Physiology, 743-761.
35318675	1:1000	Wu, Y., et al. 2022. Development of a cell‐free strategy to recover aged skeletal muscle after disuse. Journal of Physiology, .
35175105	1:1000	Wu, Y.F., et al. 2022. Optimization of a pericyte therapy to improve muscle recovery after limb immobilization. Jounal of Applied Physiology, 1020-1030.
35059739	1:500	Kim, R., et al. 2022. Ginsenoside Rg3 protects glucocorticoid‑induced muscle atrophy in vitro through improving mitochondrial biogenesis and myotube growth. Molecular Medicine Reports, 94.
34729960	not listed	Liu, Z., et al. 2022. Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole. Journal of cachexia, sarcopenia and muscle, 636-647.
34739541	not listed	Albadrani, H., et al. 2021. Angiotensin 1–7 prevents the excessive force loss resulting from 14-and 28-day denervation in mouse EDL and soleus muscle. Journal of General Physiology, .
34599649	not listed	Kato,H, et al. 2021. Advanced oxidation protein products contribute to chronic kidney disease-induced muscle atrophy by inducing oxidative stress via CD36/NADPH oxidase pathway. Journal of cachexia, sarcopenia and muscle, 1832-1847.
34325487	1:1000	Parveen, A, et al. 2021. MyD88-mediated signaling intercedes in neurogenic muscle atrophy through multiple mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, e21821.
34270178	1:1000	Fix, DK, et al. 2021. Wheel running improves fasting-induced AMPK signaling in skeletal muscle from tumor-bearing mice. Physiological reports, e14924.
34268902	1:1000	Sakai, H, et al. 2021. Exogenous insulin-like growth factor 1 attenuates cisplatin-induced muscle atrophy in mice. Journal of cachexia, sarcopenia and muscle, 1570-1581.
34262449	not listed	Park, JM, et al. 2021. Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma-Induced Cancer Cachexia. Frontiers in pharmacology, 665493.
33803124	1:1000	Paixão, AO, et al. 2021. Palmitic Acid Impairs Myogenesis and Alters Temporal Expression of miR-133a and miR-206 in C2C12 Myoblasts. International journal of molecular sciences, 2748.
33788266	not listed	Fang, W.Y., et al. 2021. Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway. Bristih Journal of Pharmacology, 2998-3016.
33737702	not listed	Bruells, CS, et al. 2021. Acute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm. Scientific reports, 6302.
33731895	not listed	Yoo, W, et al. 2021. Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor. Experimental & molecular medicine, 432-445.
33386611	1:2000	Kawanishi, N, et al. 2021. Alterations of macrophage and neutrophil content in skeletal muscle of aged versus young mice. Muscle & nerve, 600-607.
33355181	1:1000	Sin, TK., et al. 2021. Cancer-Induced Muscle Wasting Requires p38β MAPK Activation of p300p38β MAPK Activates p300 to Mediate Muscle Wasting. Cancer Research, 885-897.
33348673	1:1000	Campelj, DG, et al. 2020. The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction. Cancers, 3810.
33113850	1:500	Abrigo, J, et al. 2020. Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5. International journal of molecular sciences, 7922.
32897592	1:1000	Germinario, E., et al. 2020. Reduction of circulating sphingosine‐1‐phosphate worsens mdx soleus muscle dystrophic phenotype. Experimental Physiology, 1895-1906.
32103619	1:200	Costamagna, D, et al. 2020. Interleukin-4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma-bearing mice. Journal of cachexia, sarcopenia and muscle, 783-801.
31736871	1:1000	Counts, BR, et al. 2019. The Effect of Estradiol Administration on Muscle Mass Loss and Cachexia Progression in Female Apc Min/+ Mice. Frontiers in endocrinology, 720.
31592205	not listed	Min An, J, et al. 2019. Dietary intake of probiotic kimchi ameliorated IL-6-driven cancer cachexia. Journal of clinical biochemistry and nutrition, 109-117.
31514753	1:500	Pérez, V, et al. 2019. The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability. Acta neuropathologica communications, 147.
31312114	1:1000	Kim, CS, et al. 2019. Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle. Journal of inflammation (London, England), 17.
30943315	1:1000	Silva,WJ, et al. 2019. miR-29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophy-related genes. Acta physiologica (Oxford, England), e13278.
30922397	not listed	Liu, D, et al. 2019. IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway. Skeletal muscle, 8.
30884219	not listed	Zhang, P, et al. 2019. Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting. Journal of cachexia, sarcopenia and muscle, 557-573.
30681896	not listed	Choi, RH, et al. 2019. TRB3 regulates skeletal muscle mass in food deprivation-induced atrophy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 5654-5666.
31225455	not listed	Liu, Z, et al. 2018. p38β MAPK mediates ULK1-dependent induction of autophagy in skeletal muscle of tumor-bearing mice. Cell stress, 311-324.
30279138	1:1000	Pierucci, F, et al. 2018. Involvement of released sphingosine 1-phosphate/sphingosine 1-phosphate receptor axis in skeletal muscle atrophy. Biochimica et biophysica acta. Molecular basis of disease, 3598-3614.
29671242	not listed	Shin, K, et al. 2018. Fbxw7β is an inducing mediator of dexamethasone-induced skeletal muscle atrophy in vivo with the axis of Fbxw7β-myogenin-atrogenes. Molecular biology reports, 625-631.
29609556	not listed	Wang, F, et al. 2018. The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells. BMC cancer, 360.
29578301	1:1000	Wang, D, et al. 2018. Resveratrol Improves Muscle Atrophy by Modulating Mitochondrial Quality Control in STZ-Induced Diabetic Mice. Molecular nutrition & food research, e1700941.
29401629	1:1000	Horii, N, et al. 2018. Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 3547-3559.
29215198	1:5000	Hardee, J, et al. 2018. Inflammatory signalling regulates eccentric contraction-induced protein synthesis in cachectic skeletal muscle. Journal of cachexia, sarcopenia and muscle, 369-383.
29092819	1:250	Stouth, D, et al. 2018. Protein arginine methyltransferase expression, localization, and activity during disuse-induced skeletal muscle plasticity. American journal of physiology. Cell physiology, C177-C190.
29152137	not listed	Hu, L, et al. 2017. Emodin and rhein decrease levels of hypoxia-inducible factor-1α in human pancreatic cancer cells and attenuate cancer cachexia in athymic mice carrying these cells. Oncotarget, 88088-88020.
29021780	1:1000	Paré, MF, et al. 2017. Chronic 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Treatment Induces Phenotypic Changes in Skeletal Muscle, but Does Not Improve Disease Outcomes in the R6/2 Mouse Model of Huntington's Disease. Frontiers in neurology, 516.
28928431	1:1000	Zhang, G, et al. 2017. Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90. Nature communications, 589.
28536426	not listed	Zhang, G, et al. 2017. Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways. Scientific reports, 2273.
28286533	1:1000	Zhang, Y, et al. 2017. Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-3. Evidence-based complementary and alternative medicine : eCAM, 6268378.
27897407	not listed	Ding, H, et al. 2017. Activin A induces skeletal muscle catabolism via p38β mitogen-activated protein kinase. Journal of cachexia, sarcopenia and muscle, 202-212.
27869526	not listed	Wang, J, et al. 2017. PGC-1α over-expression suppresses the skeletal muscle atrophy and myofiber-type composition during hindlimb unloading. Bioscience, biotechnology, and biochemistry, 500-513.
26487451	not listed	Stefanis, D, et al. 2017. Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle. European journal of nutrition, 363-373.

Western Blot: Rat
PMID	Dilution	Publication
37130808	1:1000	Martin, R.A., et al. 2023. The Pathophysiology of COVID-19 and SARS-CoV-2 Infection: An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease. American Journal of Physiology. Lung Cellular and Molecular Physiology, L870-L878.
36980729	1:1000	Saroul, N., et al. 2023. Conditioned Media from Head and Neck Cancer Cell Lines and Serum Samples from Head and Neck Cancer Patients Drive Catabolic Pathways in Cultured …. Cancers, 1843.
36536512	1:1000	Raymond‐Pope, C.J., et al. 2023. Restricted physical activity after volumetric muscle loss alters whole‐body and local muscle metabolism. The Journal of Physiology, 743-761.
35318675	1:1000	Wu, Y., et al. 2022. Development of a cell‐free strategy to recover aged skeletal muscle after disuse. Journal of Physiology, .
35175105	1:1000	Wu, Y.F., et al. 2022. Optimization of a pericyte therapy to improve muscle recovery after limb immobilization. Jounal of Applied Physiology, 1020-1030.
35059739	1:500	Kim, R., et al. 2022. Ginsenoside Rg3 protects glucocorticoid‑induced muscle atrophy in vitro through improving mitochondrial biogenesis and myotube growth. Molecular Medicine Reports, 94.
34729960	not listed	Liu, Z., et al. 2022. Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole. Journal of cachexia, sarcopenia and muscle, 636-647.
34739541	not listed	Albadrani, H., et al. 2021. Angiotensin 1–7 prevents the excessive force loss resulting from 14-and 28-day denervation in mouse EDL and soleus muscle. Journal of General Physiology, .
34599649	not listed	Kato,H, et al. 2021. Advanced oxidation protein products contribute to chronic kidney disease-induced muscle atrophy by inducing oxidative stress via CD36/NADPH oxidase pathway. Journal of cachexia, sarcopenia and muscle, 1832-1847.
34325487	1:1000	Parveen, A, et al. 2021. MyD88-mediated signaling intercedes in neurogenic muscle atrophy through multiple mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, e21821.
34270178	1:1000	Fix, DK, et al. 2021. Wheel running improves fasting-induced AMPK signaling in skeletal muscle from tumor-bearing mice. Physiological reports, e14924.
34268902	1:1000	Sakai, H, et al. 2021. Exogenous insulin-like growth factor 1 attenuates cisplatin-induced muscle atrophy in mice. Journal of cachexia, sarcopenia and muscle, 1570-1581.
34262449	not listed	Park, JM, et al. 2021. Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma-Induced Cancer Cachexia. Frontiers in pharmacology, 665493.
33803124	1:1000	Paixão, AO, et al. 2021. Palmitic Acid Impairs Myogenesis and Alters Temporal Expression of miR-133a and miR-206 in C2C12 Myoblasts. International journal of molecular sciences, 2748.
33788266	not listed	Fang, W.Y., et al. 2021. Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway. Bristih Journal of Pharmacology, 2998-3016.
33737702	not listed	Bruells, CS, et al. 2021. Acute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm. Scientific reports, 6302.
33731895	not listed	Yoo, W, et al. 2021. Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor. Experimental & molecular medicine, 432-445.
33386611	1:2000	Kawanishi, N, et al. 2021. Alterations of macrophage and neutrophil content in skeletal muscle of aged versus young mice. Muscle & nerve, 600-607.
33355181	1:1000	Sin, TK., et al. 2021. Cancer-Induced Muscle Wasting Requires p38β MAPK Activation of p300p38β MAPK Activates p300 to Mediate Muscle Wasting. Cancer Research, 885-897.
33348673	1:1000	Campelj, DG, et al. 2020. The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction. Cancers, 3810.
33113850	1:500	Abrigo, J, et al. 2020. Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5. International journal of molecular sciences, 7922.
32897592	1:1000	Germinario, E., et al. 2020. Reduction of circulating sphingosine‐1‐phosphate worsens mdx soleus muscle dystrophic phenotype. Experimental Physiology, 1895-1906.
32103619	1:200	Costamagna, D, et al. 2020. Interleukin-4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma-bearing mice. Journal of cachexia, sarcopenia and muscle, 783-801.
31736871	1:1000	Counts, BR, et al. 2019. The Effect of Estradiol Administration on Muscle Mass Loss and Cachexia Progression in Female Apc Min/+ Mice. Frontiers in endocrinology, 720.
31592205	not listed	Min An, J, et al. 2019. Dietary intake of probiotic kimchi ameliorated IL-6-driven cancer cachexia. Journal of clinical biochemistry and nutrition, 109-117.
31514753	1:500	Pérez, V, et al. 2019. The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability. Acta neuropathologica communications, 147.
31312114	1:1000	Kim, CS, et al. 2019. Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle. Journal of inflammation (London, England), 17.
30943315	1:1000	Silva,WJ, et al. 2019. miR-29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophy-related genes. Acta physiologica (Oxford, England), e13278.
30922397	not listed	Liu, D, et al. 2019. IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway. Skeletal muscle, 8.
30884219	not listed	Zhang, P, et al. 2019. Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting. Journal of cachexia, sarcopenia and muscle, 557-573.
30681896	not listed	Choi, RH, et al. 2019. TRB3 regulates skeletal muscle mass in food deprivation-induced atrophy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 5654-5666.
31225455	not listed	Liu, Z, et al. 2018. p38β MAPK mediates ULK1-dependent induction of autophagy in skeletal muscle of tumor-bearing mice. Cell stress, 311-324.
30279138	1:1000	Pierucci, F, et al. 2018. Involvement of released sphingosine 1-phosphate/sphingosine 1-phosphate receptor axis in skeletal muscle atrophy. Biochimica et biophysica acta. Molecular basis of disease, 3598-3614.
29671242	not listed	Shin, K, et al. 2018. Fbxw7β is an inducing mediator of dexamethasone-induced skeletal muscle atrophy in vivo with the axis of Fbxw7β-myogenin-atrogenes. Molecular biology reports, 625-631.
29609556	not listed	Wang, F, et al. 2018. The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells. BMC cancer, 360.
29578301	1:1000	Wang, D, et al. 2018. Resveratrol Improves Muscle Atrophy by Modulating Mitochondrial Quality Control in STZ-Induced Diabetic Mice. Molecular nutrition & food research, e1700941.
29401629	1:1000	Horii, N, et al. 2018. Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 3547-3559.
29215198	1:5000	Hardee, J, et al. 2018. Inflammatory signalling regulates eccentric contraction-induced protein synthesis in cachectic skeletal muscle. Journal of cachexia, sarcopenia and muscle, 369-383.
29092819	1:250	Stouth, D, et al. 2018. Protein arginine methyltransferase expression, localization, and activity during disuse-induced skeletal muscle plasticity. American journal of physiology. Cell physiology, C177-C190.
29152137	not listed	Hu, L, et al. 2017. Emodin and rhein decrease levels of hypoxia-inducible factor-1α in human pancreatic cancer cells and attenuate cancer cachexia in athymic mice carrying these cells. Oncotarget, 88088-88020.
29021780	1:1000	Paré, MF, et al. 2017. Chronic 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Treatment Induces Phenotypic Changes in Skeletal Muscle, but Does Not Improve Disease Outcomes in the R6/2 Mouse Model of Huntington's Disease. Frontiers in neurology, 516.
28928431	1:1000	Zhang, G, et al. 2017. Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90. Nature communications, 589.
28536426	not listed	Zhang, G, et al. 2017. Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways. Scientific reports, 2273.
28286533	1:1000	Zhang, Y, et al. 2017. Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-3. Evidence-based complementary and alternative medicine : eCAM, 6268378.
27897407	not listed	Ding, H, et al. 2017. Activin A induces skeletal muscle catabolism via p38β mitogen-activated protein kinase. Journal of cachexia, sarcopenia and muscle, 202-212.
27869526	not listed	Wang, J, et al. 2017. PGC-1α over-expression suppresses the skeletal muscle atrophy and myofiber-type composition during hindlimb unloading. Bioscience, biotechnology, and biochemistry, 500-513.
26487451	not listed	Stefanis, D, et al. 2017. Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle. European journal of nutrition, 363-373.

Western Blot: Swine
PMID	Dilution	Publication
36627358	not listed	Rudar, M., et al. 2023. Prematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs. Pediatric Reasearch, .
34719946	1:1000	Rudar, M., et al. 2021. Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model. American Journal of Physiology Endocrinology and Metabolism, E737-E752.
32974749	not listed	Manjarín, R, et al. 2020. Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs. Amino acids, 1319-1335.
30239549	not listed	El-Kadi, S, et al. 2018. Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model. The American journal of clinical nutrition, 830-841.
29728917	not listed	Manjarín, R, et al. 2018. Short- and long-term effects of leucine and branched-chain amino acid supplementation of a protein- and energy-reduced diet on muscle protein metabolism in neonatal pigs. Amino acids, 943-959.

Additional Publications: Unspecified
PMID	Publication
37165186	Bilgic, S.N., et al. 2023. EDA2R–NIK signalling promotes muscle atrophy linked to cancer cachexia. Nature , 827-834.
36280388	Albadrani, H., et al. 2022. Angiotensin 1–7 increases fiber cross-sectional area and force in juvenile mouse skeletal muscle. American Journal of Physiology. Cell Physiology, C1681-C1696.
35606908	Wang, R., et al. 2022. Resveratrol ameliorates muscle atrophy in chronic kidney disease via the axis of SIRT1/FoxO1. Phytotherapy Research, 3265-3275.
34748920	Yeo, D., et al. 2022. Protective effects of extra virgin olive oil and exercise training on rat skeletal muscle against high-fat diet feeding. Journal of Nutritional Biochemistry, 108902.

Recover password

Create my account

Anti-Atrogin-1 Antibody