Our Anti-Alpha Synuclein primary antibody from PhosphoSolutions is mouse monoclonal. It detects bovine, human, mouse, pig, and rat Alpha Synuclein and is Protein G purified. It is great for use in WB, IHC, ICC.
Western blot of rat brain lysate showing specific immunolabeling of the ~15 kDa alpha synuclein protein.
Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (ChartierHarlin MC et al., 2004 and Singleton, AB et al., 2005). Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).
Protein G Purified
ICC, IHC, WB
Full length human alpha synuclein expressed in E. Coli.
Bovine, Human, Mouse, Rat
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.