Our Anti-Adenylate Cyclase III primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, and rat Adenylate Cyclase III and is antigen affinity purified. It is great for use in WB, IHC, ICC.
Immunofluorescence of a section of rat hippocampus selectively labeling the neuronal cilia with anti-adenylate cyclase III (cat. 85-AC3, 1:10,000, red), labeling nuclei with anti-MECP2 (cat. 1205-MeCP2, 1:1000,green), and Hoechst staining of nuclear DNA.
Anti-Adenylate Cyclase III Antibody
Adenylate Cyclase III
Adenylate cyclase is the enzyme which produces the "second messenger" signaling molecule, cAMP from ATP. Type III adenylate cyclase is localized to the membranes surrounding neuronal cilia. Much is currently unknown about the function of primary cilia in vertebrates, however, recent work has begun to explore their role in neuronal signaling and neurogenesis (Fuchs and Schwark, 2004; Louvi and Grove 2011).
Antigen Affinity Purified
ICC, IHC, WB
160, 200 kDa
Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat adenylate cyclase III, conjugated to keyhole limpet hemocyanin (KLH).
Human, Mouse, Rat
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.