Looking for an antibody for a specific signaling pathway?? The pathway diagrams below were produced by our scientists and design experts in an effort to provide a concise overview of the selected signaling pathways. Each pathway includes relevant product descriptions, catalog numbers and pricing information. Download yours now!!!
At the receptor level DA interacts with D2 receptors on both the presynaptic and post-synaptic membrane. Activation of the D2 receptors often inhibits the production of cAMP while DA interaction with the D1 type of DA receptors leads to an increase in cAMP. These changes in cAMP levels lead to a complex set of signals involving downstream targets of cAMP-dependent protein kinase, which in turn lead to the complex intracellular effects of DA signaling.We offer a variety of products that target proteins in the dopaminergic pathway. Check out the list!
Gamma-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. Alterations in GABA inhibition have been implicated in epilepsy, as well as anxiety, Alzheimer’s disease, dementia, schizophrenia, and alcoholism. There are two principal classes of GABA receptors: GABA-A and GABA-B receptors. GABA A receptors are coupled to an ion channel that is permeable to Cl- and are primarily responsible for the inhibitory effect of GABA. The GABA A receptor has multiple subunits α, β, and γ; each of which have multiple isoforms. The various GABA A subunits can be regulated by phosphorylation via serine/threonine kinases and tyrosine kinases which can affect membrane localization and/or function of the receptors. GABA B receptors are g-protein coupled receptors that are linked to potassium channels. As with the GABA A receptors the GABA B receptors can be regulated by phosphorylation.
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The metabotropic subunit of glutamate receptors is called the metabotropic glutamate receptor (mGluR). mGluRs are g-protein coupled receptors and they also have multiple subunits: mGluR1-mGluR8. Glutamatergic function plays key roles in many diseases including dementia, Alzheimer’s disease, epilepsy, stroke as well as a number of other neurological conditions.We offer a variety of products that target proteins in the glutamatergic pathway. Check out the list!
Synaptic vesicles are membranous structures that contain neurotransmitters and fuse with the presynaptic membrane during exocytosis of the neurotransmitters. There are a large number of synaptic vesicle associated proteins that are thought to influence numerous vesicle functions (e.g. membrane association and fusion, vesicle recycling and neurotransmitter transport). Most prominent among these are synapsin and synaptophysin, which are both extremely widely used as neuronal markers for synaptic vesicles. Virtually all of these synaptic vesicle proteins are modulated by protein phosphorylation.
We offer a variety of products that target proteins in the synaptic vesicles. Check out the list!