Visinin-Like Protein 1 (VSNL1) Antibody

Catalog #: 2145-VSNL1 Categories: , , Datasheet:

$109.00$365.00

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Neuronal marker that works great in IHC!

Formulation:
Protein G Purified
Specificity:
Rat, Mouse, Human, Bovine
Applications:
WB 1:2,000IF 1: 500
Species:
Mouse Monoclonal
Gene Name:
VSNL1
Molecular Reference:
~ 22 kDa
Cite This Antibody:
PhosphoSolutions Cat# 2145-VSNL1, RRID:AB_2492285
Antigen/Purification: ExpandCollapse

The antigen is recombinant full length human VSNL1 expressed in and purified from E. Coli.

The antibody is Protein G purified culture supernatant.

Biological Significance: ExpandCollapse

Visinin-like protein 1 (VSNL1), also known as VILIP1, is a calcium sensor protein expressed exclusively in neurons. Highest levels of VSNL1 expression are found in cerebellar Purkinje cells. VSNL1 has been implicated in the modulation of cell signaling cascades via regulation of adenyl cyclase activity (Braunewell et al., 1997). Additionally, VSNL1 has been associated with amyloid plaques and neurofibrillar tangles in Alzheimer’s disease (Schnurra et al., 2001).

Storage

100 ul liquid containing 10 mM sodium azide.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Braunewell KH, Spilker C, Behnisch T, Gundelfinger ED (1997) The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity. J. Neurochem. 68 (5): 2129–39.

Schnurra I, Bernstein HG, Riederer P, Braunewell KH (2002) The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer’s disease and promotes cell death and tau phosphorylation in vitro: a link between calcium sensors and Alzheimer’s disease? Neurobiol. Dis. 8 (5): 900–9.

Visinin-Like Protein 1 (VSNL1) Antibody
Western blot of rat cerebellar lysate showing specific immunolabeling of the ~22 kDa VSNL1 protein.
Visinin-Like Protein 1 (VSNL1) Antibody
Immunofluorescence of rat cerebellum showing strong synaptic staining of VSNL1 (green) in the molecular layer (ML) and MAP2 (cat. # 1100-MAP2) in red.