Works great in IHC!
- 100 µl
- Protein G Purified
- Most mammals
- WB 1:10,000IHC 1:1,000
- Mouse monoclonal
- Gene Name:
- Molecular Reference:
- ~55 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 2020-TUB, RRID:AB_2492275
The antigen is a synthetic peptide corresponding to beta III tubulin.
The antibody is Protein G purified culture supernatant.
Biological Significance: ExpandCollapse
Tubulin is the major constituent of microtubules, existing as a heterodimer of the α and β subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)