TFAM (Transcription Factor A, mitochondrial) Antibody, Human

Catalog #: 1999-hTFAM Categories: , Datasheet:

$99.00$310.00

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Rabbit polyclonal antibody

Formulation:
Neat serum
Species Reactivity:
Human
Applications:
WB 1:2000
Species:
Rabbit Polyclonal
Gene Name:
TFAM
Molecular Reference:
~24 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1999-hTFAM, RRID:AB_2571641
Antigen/Purification: ExpandCollapse

The antigen is a native recombinant human TFAM protein with c-terminal 6-his tag.

The antibody is serum.

Biological Significance: ExpandCollapse

Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia (Hayashi et al., 2008). More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice (Morimoto et al., 2012).

Synonyms: ExpandCollapse

• Tanscription factor 6-like 1 antibody
• Mitochondrial transcription factor 1 antibody
• mitochondrial transcription factor A antibody
• MtTF1 antibody
• mtTFA antibody
• TCF 6 antibody
• TCF-6 antibody
• TCF6 antibody
• TCF6L1 antibody
• TCF6L2 antibody
• TCF6L3 antibody
• TFAM antibody
• TFAM_HUMAN antibody
• Transcription factor 6 antibody
• Transcription factor 6 like 2 (mitochondrial transcription factor) antibody
• Transcription factor 6 like 2 antibody
• Transcription factor 6-like 2 antibody
• transcription factor 6-like 3 antibody
• Transcription factor A, mitochondrial antibody
• Transcription factor A, mitochondrial antibody
• Transcription factor A, mitochondrial precursor antibody

Storage

100 ul neat serum.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi-Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H (2008) Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice. J Neurosci. 28(34):8624-34

Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T, Kang D, Ide T, Abe K (2012) Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice. J Neurosci Res. 90(6):1200-8. Epub 2012 Feb 22

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TFAM (Transcription Factor A, mitochondrial) Antibody, Human
Western blot of HeLa lysate showing specific immunolabeling of the ~24 kDa TFAM protein.

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