TFAM (Transcription Factor A, mitochondrial) Antibody, Human

Catalog #: 1999-hTFAM Categories: , Datasheet:

$99.00$310.00

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Rabbit polyclonal antibody

Formulation:
Neat serum
Specificity:
Human
Applications:
WB 1:2,000
Species:
Rabbit Polyclonal
Molecular Reference:
~24 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1999-hTFAM, RRID:AB_2571641
Antigen/Purification: ExpandCollapse

The antigen is a native recombinant human TFAM protein with c-terminal 6-his tag.

The antibody is serum.

Biological Significance: ExpandCollapse

Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia (Hayashi et al., 2008). More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice (Morimoto et al., 2012).

Storage

100 ul neat serum.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi-Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H (2008) Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice. J Neurosci. 28(34):8624-34

Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T, Kang D, Ide T, Abe K (2012) Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice. J Neurosci Res. 90(6):1200-8. Epub 2012 Feb 22

TFAM (Transcription Factor A, mitochondrial) Antibody, Human
Western blot of HeLa lysate showing specific immunolabeling of the ~24 kDa TFAM protein.

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