Testicular Receptor 2 (TR2) Antibody

Our Testicular Receptor 2 rabbit polyclonal antibody is formulated as neat serum, and great in WB.

Catalog #: 2002-TR2 Categories: , Datasheet:

$109.00$325.00

  • SizePrice
Clear
Formulation:
Neat serum
Species Tested:
Human, Mouse, Rat
Applications:
WB 1:1000 Don't see your application?
Host Species:
Rabbit Polyclonal
Gene Name:
NR2C1
Molecular Weight:
~64 kDa
Cite This Antibody:
PhosphoSolutions Cat# 2002-TR2, RRID:AB_2492264
Antigen/Purification: ExpandCollapse

The antigen is a fusion protein from N-terminal peptide of mouse TR2.

The antibody is neat serum.

Biological Significance: ExpandCollapse

Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. It is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA directly interacting with HDAC3 and HDAC4 via DNA-binding domains (Franco et al., 2003). TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands (Hun et al., 2002). In addition, TR2 has recently been shown to form a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression (Lin et al., 2008).

Synonyms: ExpandCollapse

• NR2C 1 antibody
• NR2C1 antibody
• NR2C1_HUMAN antibody
• NUCLEAR HORMONE RECEPTOR TR2 antibody
• Nuclear receptor subfamily 2 Group C isoform antibody
• Nuclear receptor subfamily 2 group C member 1 antibody
• Orphan nuclear receptor TR2 antibody
• Testicular receptor 2 antibody
• TR 2 antibody
• TR2 antibody
• TR2-11 antibody

Storage

100 µl neat serum. Adequate amount of material to conduct 10-mini Western Blots.

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Product Specific Protocols

Western Blotting

Click here to view our protocols page for Western blotting and lysate preparation.

Product Specific References for Applications and Species

Western Blot: Human | Mouse


Western Blot: Human
PMID Dilution Publication
21670149 not listed Cui, S., et al. 2011 Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Molecular and Cellular Biology, 31(16), pp.3298-3311.
17974920 not listed Tanabe, O., et al. 2007 The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes & Development, 21(21), pp.2832-2844.
17431400 not listed Tanabe, O., et al. 2007 Embryonic and fetal β‐globin gene repression by the orphan nuclear receptors, TR2 and TR4. The EMBO Journal, 26(9), pp.2295-2306.


Western Blot: Mouse
PMID Dilution Publication
24662048 not listed Cui, S., et al. 2014 PGC-1 coactivator activity is required for murine erythropoiesis. Molecular and Cellular Biology, 34(11), pp.1956-1965.
22042865 not listed Campbell, A.D., et al. 2011 Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proceedings of the National Academy of Sciences, 108(46), pp.18808-18813.
21670149 not listed Cui, S., et al. 2011 Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Molecular and Cellular Biology, 31(16), pp.3298-3311.
17974920 not listed Tanabe, O., et al. 2007 The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes & Development, 21(21), pp.2832-2844.
17431400 not listed Tanabe, O., et al. 2007 Embryonic and fetal β‐globin gene repression by the orphan nuclear receptors, TR2 and TR4. The EMBO Journal, 26(9), pp.2295-2306.

  • 5 – Excellent (publishable, performed ideally)
  • 4 – Good (publishable, would use again)
  • 3 – Average (publishable, might use again)
  • 2 – Poor (unpublishable, signal inconclusive)
  • 1 – No signal (unpublishable)
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