Testicular Receptor 2 (TR2) Antibody

Catalog #: 2002-TR2 Category: Datasheet:

$310.00

Rabbit polyclonal antibody

Size:
100 µl
Formulation:
Neat serum
Specificity:
Rat, Mouse, Human
Applications:
WB 1:1,000
Species:
Rabbit
Molecular Reference:
~64 kDa
Cite This Antibody:
PhosphoSolutions Cat# 2002-TR2, RRID:AB_2492264
Antigen/Purification: ExpandCollapse

The antigen is a fusion protein from N-terminal peptide of mouse TR2.

The antibody is neat serum.

Biological Significance: ExpandCollapse

Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. It is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA directly interacting with HDAC3 and HDAC4 via DNA-binding domains (Franco et al., 2003). TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands (Hun et al., 2002). In addition, TR2 has recently been shown to form a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression (Lin et al., 2008).

Storage

Neat serum.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Franco PJ, Li G, Wei LN (2003) Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. Mol Cell Endocrinol. 206(1-2):1-12.

Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C. (2002) Suppression of estrogen receptor- mediated transcription and cell growth by interaction with TR2 orphan receptor. J Biol Chem. 2002 277(37):33571-9.

Lin TJ, Yang RY, Lee HJ. (2008) Collective repression of the hepatitis B virus enhancer II by human TR4 and TR2 orphan receptors. Hepatol Res. 38(1):79-84.

Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YT, Chang C, Yamamoto M, Tanimoto K, Engel JD. “Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4.” EMBO J. 2007, 26:2295-306.

Testicular Receptor 2 (TR2) Antibody
Western blot of rat testicular lysate showing specific immunolabeling of the ~64 kDa TR2 protein.

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