Tau Antibody

Catalog #: 1998-TAU Categories: , , Datasheet:

$99.00$310.00

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Excellent neuronal axon marker!

Formulation:
Total IgY fraction
Specificity:
Rat, Human
Applications:
WB 1:10,000IF 1:1,000
Species:
Chicken Polyclonal
Gene Name:
MAPT
Molecular Reference:
~48 kDa, ~65 kDa & ~75 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1998-TAU, RRID:AB_2492256
Antigen/Purification: ExpandCollapse

The antigen is a recombinant full length human tau expressed in and purified from E. Coli.

The antibody is total IgY fraction.

Biological Significance: ExpandCollapse

Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy.

Storage

100 ul liquid containing 10 mM sodium azide.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Bio Oct; 101(4):1371-8.

Goedert M. and Jakes R. (1990) Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 9, 4225-4230

Tau Antibody
Western blot of rat cortical lysate showing specific immunolabeling of the ~48 kDa, ~65 kDa & ~75 kDa tau isoforms.
Immunofluorescence of cultured rat hippocampal neurons showing staining of tau in red along the neuronal processes.

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