Great for use in IHC!
- Protein G Purified
- 100% Homology:
- Rat, Human, Porcine
- WB 1:1,000IHC 1:100
- Mouse monoclonal
- Gene Name:
- Molecular Reference:
- ~36 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 1990-STX, RRID:AB_2492254
The antigen is a synaptic immunoprecipitate (crude) from human brain.
The antibody is Protein G purified culture supernatant.
Biological Significance: ExpandCollapse
Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).