Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- Expected Reactivity:
- Rat, Mouse, Human, Bovine, Chicken, Non-human primate, Zebra fish, Canine
- WB 1:1000IHC 1:400
- Gene Name:
- Molecular Weight:
- ~60 kDa - 62 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p1570-309, RRID:AB_2492253
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser309 of synaptotagmin.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: ExpandCollapse
Synaptotagmin is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis (Fernandez-Chacon et al., 2001; Wang et al., 2003). Moreover, recent studies indicate that the protein also plays a key role in endocytosis (Poskanzer et al., 2003). Synaptotagmin can be phosphorylated by multiple protein kinases and this may play a key role in modulation of synaptotagmin’s ability to influence both the exocytotic and endocytotic components of synaptic transmission (Hilfiker et al., 1999; Lee et al., 2004).
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