Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- 100% Homology:
- Rat, Mouse, Human, Bovine, Chicken, Non-human primate
- WB 1:1,000
- Gene Name:
- Molecular Reference:
- ~65 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 1975-STG, RRID:AB_2492251
The antigen is a synthetic peptide corresponding to amino acid residues within the synaptotagmin I protein.
The antibody is prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Biological Significance: ExpandCollapse
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release (Littleton and Bellen 1995). Recent studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane fusion (Zhang et al., 2002). It has recently been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size (Poskanzer et al., 2006).