Synaptobrevin (VAMP) Antibody

Catalog #: 1933-SYB Categories: , Datasheet:

$109.00$365.00

  • SizePrice
Clear

Mouse monoclonal antibody

Formulation:
Protein G Purified
Species Reactivity:
Rat, Mouse, Human, Bovine, Porcine, Rabbit
Applications:
WB 1:1000IHC 1:100
Species:
Mouse
Gene Name:
VAMP1/2
Molecular Reference:
~16 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1933-SYB, RRID:AB_2492248
Antigen/Purification: ExpandCollapse

The antigen is a synaptic immunoprecipitate (crude) from human brain.

The antibody is Protein G purified culture supernatant.

Biological Significance: ExpandCollapse

Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive deficits in Alzheimer’s disease (Sze et al., 2000).

Synonyms: ExpandCollapse

• SYB antibody
• SYB1 antibody
• Synaptobrevin 1 antibody
• VAMP antibody
• VAMP1 antibody
• Vesicle associated membrane protein 1 antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

General References

Deák F, Schoch S, Liu X, Südhof TC, Kavalali ET (2004) Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol. 2004 Nov;6(11):1102-8.

Sze CI, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ (2000) Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer’s disease brains. J Neurol Sci.175(2):81-90.

Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex (1993). Brain Research 609, 9-20.

Reviews

There are no reviews yet.

Be the first to review “Synaptobrevin (VAMP) Antibody”

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Synaptobrevin (VAMP) Antibody
Western blot of rat brain lysate showing specific immunolabeling of the ~ 16 kDa synaptobrevin protein.

You may also like…