Mouse monoclonal antibody
- Protein G Purified
- 100% Homology:
- Rat, Mouse, Human, Bovine, Porcine, Rabbit
- WB 1:1,000IHC 1:100
- Gene Name:
- Molecular Reference:
- ~16 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 1933-SYB, RRID:AB_2492248
The antigen is a synaptic immunoprecipitate (crude) from human brain.
The antibody is Protein G purified culture supernatant.
Biological Significance: ExpandCollapse
Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive deficits in Alzheimer’s disease (Sze et al., 2000).