Affinity purified from pooled serum. Learn more.

SNAP25 Antibody

Catalog #: 1905-SNAP Categories: , , , Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Rat, Mouse, Human, Bovine, Chicken, Non-human primate, Zebra fish, Canine, Guinea Pig
Applications:
WB 1:1000
Species:
Rabbit polyclonal
Gene Name:
SNAP25
Molecular Reference:
~25 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1905-SNAP, RRID:AB_2492238
Antigen/Purification: ExpandCollapse

The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat SNAP25 conjugated to keyhole limpet hemocyanin (KLH).

The antibody is prepared from pooled rabbit serum by affinity purification via chromatography on an affinity column made with the C-terminal peptide used as antigen.

Biological Significance: ExpandCollapse

SNAP25 (Synaptosomal associated protein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer’s Disease (Greber et al.,1999). In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia (Fatemi et al., 2001).

Synonyms: ExpandCollapse

• bA416N4.2 antibody
• Bdr antibody
• CMS18 antibody
• dJ1068F16.2 antibody
• FLJ23079 antibody
• HGNC:11132 antibody
• MGC105414 antibody
• MGC139754 antibody
• Resistance to inhibitors of cholinesterase 4 homolog antibody
• RIC 4 antibody
• RIC4 antibody
• SEC 9 antibody
• SEC9 antibody
• SNAP 25 antibody
• SNAP antibody
• SNAP-25 antibody
• SNAP-25B antibody
• SNAP25 antibody
• SNP 25 antibody
• SNP25 antibody
• SNP25_HUMAN antibody
• sp antibody
• SUP antibody
• Super protein antibody
• Synaptosomal associated 25 kDa protein antibody
• Synaptosomal associated protein antibody
• Synaptosomal associated protein 25 antibody
• Synaptosomal associated protein 25kDa antibody
• Synaptosomal-associated 25 kDa protein antibody
• Synaptosomal-associated protein 25 antibody
• Synaptosomal-associated protein, 25-KD antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

General References

Fatemi SH, Sidwell R, Kist D, Akhter P, Meltzer HY, Bailey K, Thuras P, Sedgwick J (1998) Differential expression of synaptosome-associated protein 25 kDa (Snap25) in hippocampi of neonatal mice following exposure to human influenza virus in utero. Brain Res 800(1):1-9.

Greber S, Cairns N, Lubec G, Fountoulakis M (1999) Decreased levels of the synaptosomal associated protein 25 in the brains of patients with Down Syndrome and Alzheimer’s Disease. Electrophoresis 20 (4-5):928-34.

Ando K, Kudo Y, Takahashi M (2005) Negative regulation of neurotransmitter release by calpain: a possible specific involvement of Snap25 cleavage. J Neurochem 94(3):651-8.

Fatemi SH, Earle JA, Stary JM, Lee S, Sedgwick J (2001) Altered levels of the synaptosomal associated protein Snap25 in hippocampus of patients with mood disorders and Schizophrenia. Neuroreport. 12(15): 3257-62.

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SNAP25 Antibody
Western blot of rat cortical lysate showing specific labeling of the ~25 kDa SNAP25 protein.

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