Rabbit polyclonal antibodyPooled Serum
- Affinity Purified from Pooled Serum
- 100% Homology:
- Rat, Mouse, Human, Bovine, Chicken, Non-human primate, Zebra fish, Canine, Guinea Pig
- WB 1:1000
- Rabbit polyclonal
- Gene Name:
- Molecular Reference:
- ~25 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 1905-SNAP, RRID:AB_2492238
The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat SNAP25 conjugated to keyhole limpet hemocyanin (KLH).
The antibody is prepared from pooled rabbit serum by affinity purification via chromatography on an affinity column made with the C-terminal peptide used as antigen.
Biological Significance: ExpandCollapse
SNAP25 (Synaptosomal associated protein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer’s Disease (Greber et al.,1999). In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia (Fatemi et al., 2001).