Mouse monoclonal antibody
- Protein G Purified
- Rat, Mouse, Human, Bovine
- WB 1:2,000IF 1: 1,000
- Mouse Monoclonal
- Molecular Reference:
- ~49 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 1900-SAP, RRID:AB_2492236
The antigen is a recombinant full length human SAP49 expressed in and purified from E. Coli.
The antibody is Protein G purified from tissue culture supernatant.
Biological Significance: ExpandCollapse
The spliceosome associated protein of ~49 kDa (SAP49), also known as SF3B4, is a widely expressed nuclear splicing factor that has been shown to have RNA binding activity as well as direct interaction with SAP145 (Champion-Arnaud and Reed 1994). The SAP145-SAP49 complex has recently been implicated in cell cycle progression as Vpr (viral protein 1 of HIV-1) has been shown to bind SAP145 thus interfering with the proper formation and functioning of the SAP145-SAP49 complex (Terada and Yasuda 2006).