SAP49 Antibody

Catalog #: 1900-SAP Categories: , Datasheet:

$310.00$365.00

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Mouse monoclonal antibody

Formulation:
Protein G Purified
Species Reactivity:
Rat, Mouse, Human, Bovine
Applications:
WB 1:2000IF 1: 1000
Species:
Mouse Monoclonal
Gene Name:
SF3B4
Molecular Reference:
~49 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1900-SAP, RRID:AB_2492236
Antigen/Purification: ExpandCollapse

The antigen is a recombinant full length human SAP49 expressed in and purified from E. Coli.

The antibody is Protein G purified from tissue culture supernatant.

Biological Significance: ExpandCollapse

The spliceosome associated protein of ~49 kDa (SAP49), also known as SF3B4, is a widely expressed nuclear splicing factor that has been shown to have RNA binding activity as well as direct interaction with SAP145 (Champion-Arnaud and Reed 1994). The SAP145-SAP49 complex has recently been implicated in cell cycle progression as Vpr (viral protein 1 of HIV-1) has been shown to bind SAP145 thus interfering with the proper formation and functioning of the SAP145-SAP49 complex (Terada and Yasuda 2006).

Synonyms: ExpandCollapse

• AFD1 antibody
• Hsh49 antibody
• MGC10828 antibody
• Pre mRNA splicing factor SF3b 49 kDa subunit antibody
• Pre-mRNA-splicing factor SF3b 49 kDa subunit antibody
• SAP 49 antibody
• SAP49 antibody
• Sf3b4 antibody
• SF3B4 antibody
• SF3B4_HUMAN antibody
• SF3b49 antibody
• SF3b50 antibody
• Spliceosomal protein antibody
• Spliceosome associated protein (U2 snRNP) antibody
• Spliceosome associated protein 49 antibody
• Spliceosome-associated protein 49 antibody
• Splicing factor 3b subunit 4 49kDa antibody
• Splicing factor 3B subunit 4 antibody

Storage

100 µl liquid containing 10 mM sodium azide.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Champion-Arnaud P, Reed R. (1994) The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. Genes Dev. 8(16):1974-83.

Terada Y, Yasuda Y. (2006) Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145. Mol Cell Biol. 26(21):8149-58

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SAP49 Antibody
Western blot of HeLa lysate showing specific immunolabeling of the ~49 kDa SAP49 protein.
SAP49 Antibody
Immunofluorescence of HeLa cells showing strong granular nuclear staining of SAP49 in red and vimentin (cat. # 2105-VIM) in green.

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