Mouse monoclonal antibody
- 100 µl
- Protein G Purified
- Rat, Mouse
- WB 1:1,000
- Cite This Antibody:
- PhosphoSolutions Cat# 1320-RXRB, RRID:AB_2492230
The antigen is a hinge peptide corresponding to amino acids from the mouse retinoid X receptor, β- isotype.
The antibody is prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a Protein G column.
Biological Significance: ExpandCollapse
Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).