Retinoid X Receptor Antibody, β-Isotype

Catalog #: 1320-RXRB Category: Datasheet:

$109.00$365.00

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Mouse monoclonal antibody

Formulation:
Protein G Purified
Species Reactivity:
Rat, Mouse
Applications:
WB 1:1000
Species:
Mouse
Gene Name:
RXRB
Cite This Antibody:
PhosphoSolutions Cat# 1320-RXRB, RRID:AB_2492230
Antigen/Purification: ExpandCollapse

The antigen is a hinge peptide corresponding to amino acids from the mouse retinoid X receptor, β- isotype.

The antibody is  prepared from tissue culture supernatant by ammonium sulfate precipitation followed by purification on a Protein G column.

Biological Significance: ExpandCollapse

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

Synonyms: ExpandCollapse

• DAUD I6 antibody
• DAUDI6 antibody
• H 2RIIBP antibody
• H2RIIBP antibody
• MGC1831 antibody
• MHC class I promoter binding protein antibody
• NR2B2 antibody
• nuclear receptor subfamily 2 group B member 2 antibody
• RCoR 1 antibody
• RCoR1 antibody
• Retinoic acid receptor RXR beta antibody
• RXR beta antibody
• RXRB antibody
• RXRbeta antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

General References

Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6:712-720.

Joshi S, Guleria R, Pan J, Dipette D, Singh US (2005) Retinoic acid receptors and tissue-trans-glutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene advance online publication 12 September 2005; doi: 10.1038/sj.onc.1209027.

Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275-293.

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Retinoid X Receptor Antibody, β-Isotype
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~48 kDa RXR-β protein.

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