Our Anti-Retinoic Acid Receptor, ß-Isotype primary antibody from PhosphoSolutions is mouse monoclonal. It detects human and rat Retinoic Acid Receptor, ß-Isotype and is Protein G purified. It is great for use in WB.
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~48 kDa RAR-β isotype.
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X receptors (RXRs) family (RXRα, β and γ) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
Protein G Purified
Monoclonal
336
IgG1
WB
Mouse
RARB
48 kDa
Synthetic peptide corresponding to amino acid residues from the N-terminal region of human Retinoic Acid Receptor, ß-Isotype, conjugated to keyhole limpet hemocyanin (KLH). The antigen is identical in both β1 and β2 isoforms.
Human, Rat
Canine, Guinea Pig, Mouse, Non-Human Primate
AB_2492229
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Liquid
Prepared from tissue culture supernatant by ammonium sulfate precipitation followed by purification on a Protein G column.
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
WB: 1:1000
WB Brain: 1:1000
Unconjugated
Specific for endogenous levels of the ~48 kDa RAR-ß isotype.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Abu, J., Batuwangala, M., Herbert, K. and Symonds, P., 2005. Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. The Lancet Oncology, 6(9), pp.712-720. PMID: 16129372
Joshi, S., Guleria, R., Pan, J., DiPette, D. and Singh, U.S., 2006. Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene, 25(2), p.240. PMID: 16158052
Lane, M.A. and Bailey, S.J., 2005. Role of retinoid signalling in the adult brain. Progress in Neurobiology, 75(4), pp.275-293. PMID: 15882777
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