Retinoic Acid Receptor Antibody, β-Isotype, Human

Catalog #: 1340-RXRB Category: Datasheet:


  • SizePrice

Mouse monoclonal antibody

Protein G Purified
Species Reactivity:
Rat, Mouse, Human, Non-human primate, Canine, Guinea Pig
WB 1:1000
Gene Name:
Molecular Weight:
~48 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1340-RXRB, RRID:AB_2492229
Antigen/Purification: ExpandCollapse

The antigen is a  peptide corresponding to amino acids from N-terminal region of human retinoic acid receptor, ?-isotype. The antigen is identical in both ?1 and ?2 isoforms.

The antibody is prepared from tissue culture supernatant by ammonium sulfate precipitation followed by purification on a Protein G column.

Biological Significance: ExpandCollapse

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X receptors (RXRs) family (RXR?, ? and ?) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

Synonyms: ExpandCollapse

• HAP antibody
• HBV-activated protein antibody
• NR1B2 antibody
• Nuclear receptor subfamily 1 group B member 2 antibody
• RAR B antibody
• RAR beta antibody
• RAR epsilon antibody
• RAR-beta antibody
• RAR-epsilon antibody
• RARB antibody
• RARB_HUMAN antibody
• Retinoic acid receptor beta 2 antibody
• Retinoic acid receptor beta 4 antibody
• Retinoic acid receptor beta 5 antibody
• Retinoic acid receptor beta antibody
• Retinoic acid receptor beta polypeptide antibody
• RRB2 antibody


100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

General References

Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6:712-720.

Joshi S, Guleria R, Pan J, Dipette D, Singh US (2005) Retinoic acid receptors and tissue-trans-glutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene advance online publication 12 September 2005; doi: 10.1038/sj.onc.1209027.

Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275-293.

  • 5 – Excellent (publishable, performed ideally)
  • 4 – Good (publishable, would use again)
  • 3 – Average (publishable, might use again)
  • 2 – Poor (unpublishable, signal inconclusive)
  • 1 – No signal (unpublishable)
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Retinoic Acid Receptor Antibody, β-Isotype, Human
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~48 kDa RAR-? isotype.

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