Retinoic Acid Receptor Antibody, α-Isotype, Human

Catalog #: 1330-RXRA Category: Datasheet:

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Mouse monoclonal antibody

Formulation:
Protein G Purified
Species Reactivity:
Rat, Mouse, Human, Bovine, Canine, Guinea Pig
Applications:
WB 1:1000
Species:
Mouse
Gene Name:
RARA
Molecular Reference:
~48 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1330-RXRA, RRID:AB_2492228
Antigen/Purification: ExpandCollapse

The antigen is a peptide corresponding to amino acid residues from the N-terminal region of human retinoic acid receptor, α-isotype.

The antibody is prepared from tissue culture supernatant by ammonium sulfate precipitation followed  purification on a Protein G column.

Biological Significance: ExpandCollapse

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

Synonyms: ExpandCollapse

• NR1B1 antibody
• Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody
• Nuclear receptor subfamily 1 group B member 1 antibody
• Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody
• RAR alpha antibody
• RAR antibody
• RAR-alpha antibody
• rara antibody
• RARA_HUMAN antibody
• RARalpha antibody
• RARalpha1 antibody
• Retinoic acid nuclear receptor alpha variant 1 antibody
• Retinoic acid nuclear receptor alpha variant 2 antibody
• Retinoic acid receptor alpha antibody
• Retinoic acid receptor alpha polypeptide antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

General References

Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6:712-720.

Joshi S, Guleria R, Pan J, Dipette D, Singh US (2005) Retinoic acid receptors and tissue-trans-glutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene advance online publication 12 September 2005; doi: 10.1038/sj.onc.1209027.

Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275-293.

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Retinoic Acid Receptor Antibody, α-Isotype, Human
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~48 kDa RAR-α protein.

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