Affinity purified from pooled serum. Learn more.

Rabphilin 3A (Ser234) Antibody

Catalog #: p1553-234 Category: Datasheet:

$109.00$365.00

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Rabbit polyclonal antibody

Pooled Serum
Formulation:
Affinity Purified from Pooled Serum
Species Reactivity:
Rat, Mouse
Applications:
WB 1:1000IHC 1:400
Species:
Rabbit
Gene Name:
RPH3A
Molecular Reference:
~82 kDa
Cite This Antibody:
PhosphoSolutions Cat# p1553-234, RRID:AB_2492222
Antigen/Purification: ExpandCollapse

The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser234 of rabphilin 3A.

The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.

Biological Significance: ExpandCollapse

Rabphilin-3A is a peripheral membrane protein that binds Ca2+ and phospholipids and is attached to synaptic vesicle membranes (Geppert et al., 1994; Li et al., 1994). The expression of rabphilin 3A is reduced in an animal model of Huntington’s disease (Smith et al., 2005). Rabphilin can be phosphorylated at Ser234 by both CAM kinase II and PKA and this phosphorylation has been suggested to regulate neuronal activity during development in a synapse-specific manner (Fykse et al., 1995; Foletti and Scheller, 2001).

Synonyms: ExpandCollapse

• Exophilin 1 antibody
• Exophilin-1 antibody
• Exophilin1 antibody
• KIAA0985 antibody
• Rabphilin 3A homolog antibody
• Rabphilin-3A antibody
• Rabphilin3A antibody
• RP3A antibody
• RP3A_HUMAN antibody
• Rph 3a antibody
• Rph3a antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg BSA per ml and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

Product Specific References

Stanic, J., Mellone, M., Napolitano, F., Racca, C., Zianni, E., Minocci, D., Ghiglieri, V., Thiolat, M.L., Li, Q., Longhi, A. and De Rosa, A., 2017. Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias. Neurobiology of Disease. PMID: 28823933

Leal-Ortiz, S., Waites, C.L., Terry-Lorenzo, R., Zamorano, P., Gundelfinger, E.D. and Garner, C.C., 2008. Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis. The Journal of cell biology, 181(5), pp.831-846.  PMID: 18519737

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Rabphilin 3A ser234 Antibody
Western blot of rat brain lysate showing specific immunolabeling of the ~82 kDa rabphilin 3A phosphorylated at Ser234.
Rabphilin 3A ser234 Antibody
Immunostaining of 14 DIV rat cortical neurons showing rabphilin when phosphorylated at Ser234 in red and PSD95 in green. Photo courtesy of Gang Liu.

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