Rabbit polyclonal antibodyPooled Serum
- 100 µl
- Affinity Purified from Pooled Serum
- Rat, Mouse, Human, Bovine, Non-human primate, Canine
- WB 1:1000
- Molecular Reference:
- ~82 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 1825-RBP, RRID:AB_2492221
The antigen is a synthetic peptide corresponding to amino acid residues from the C-terminal region of rabphilin 3A.
The antibody is prepared from pooled rabbit serum by affinity purification on a column to which the C-terminal peptide immunogen was coupled.
Biological Significance: ExpandCollapse
Rabphilin-3A is a peripheral membrane protein that binds Ca2+ and phospholipids and is attached to synaptic vesicle membranes (Geppert et al., 1994;Li et al., 1994). The expression of rabphilin 3A is reduced in an animal model of Huntington’s disease (Smith et al., 2005). Rabphilin can be phosphorylated at Ser234 by both CAM kinase II and PKA and this phosphorylation has been suggested to regulate neuronal activity during development in a synapse-specific manner (Fykse et al., 1995;Foletti and Scheller, 2001).