Periostin Pan Antibody

Catalog #: 1622-PERI Categories: , Datasheet:

$365.00

Rabbit polyclonal antibody

Size:
100 µl
Formulation:
Affinity purified
Specificity:
Rat, Mouse, Human, Chicken
Applications:
WB 1:1,000IHC 1:100
Species:
Rabbit
Molecular Reference:
~93 kDa
Cite This Antibody:
PhosphoSolutions Cat# 1622-PERI, RRID:AB_2492206
Antigen/Purification: ExpandCollapse

The antigen is a peptide from fasciclin domain 1 of mouse periostin.

The antibody is affinity purified.

Biological Significance: ExpandCollapse

Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has recently been shown to promote collagen fibrogenesis, inhibit differentiation of progenitor cells into cardiomyocytes and to be essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008)

Storage

Liquid in PBS. Contains no preservative.

For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least 1 year. Avoid freeze/thaw cycles.

General References

Kruzynska-Frejtag A, Wang J, Rogers R, Krug E, Hoffman S, Markwald RR, Conway SJ. (2004) Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal interaction. Develop Dynamics, 229:857-868.

Norris RA, Borq TK, Butcher JT, Baudino TA, Banerjee I, Markwald RR (2008) Neonatal and adult cardiovascular pathophysiological remodeling and repair: developmental role of periostin. Ann NY Acad Sci. 1123:30-40.

Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T, Potts JD, Goodwin RL, Davis J, Hoffman S, Wen X, Sugi Y, Kern CB, Mjaatvedt CH, Turner DK, Oka T, Conway SJ, Molkentin JD, Forgacs G, Markwald RR. (2007) Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem. 101(3):695-711.

Periostin Pan Antibody
Western blot of rat lung lysate showing specific immunolabeling of the ~93 kDa periostin protein triplet.

You may also like…