Affinity purified from pooled serum. Learn more.

p38 MAPK (Thr180, Tyr182) Antibody

Name: p38 MAPK (Thr180, Tyr182) Antibody
SKU: p190-1802
Price: 365 USD
Availability: InStock

Catalog #: p190-1802 Category: Signal Transduction Datasheet:

$109.00 – $365.00

Rabbit polyclonal antibody

Pooled Serum

Formulation:: Affinity Purified from Pooled Serum
Species Reactivity:: Rat, Mouse, Human, Bovine, Chicken, Non-human primate, Zebra fish, Canine
Applications:: WB 1:1000IHC 1:250
Species:: Rabbit
Gene Name:: MAPK14
Molecular Reference:: ~39 kDa
Cite This Antibody:: PhosphoSolutions Cat# p190-1802, RRID:AB_2492195

Antigen/Purification: ExpandCollapse

The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr¹⁸⁰ and phospho-Tyr¹⁸² of rat p38 MAPK.

The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.

Biological Significance: ExpandCollapse

The three Mitogen-Activated Protein Kinases (MAPKs) are evolutionarily conserved protein kinases that control a vast array of cellular processes. p38 MAPK is one of these kinases and it is activated by both inflammatory cytokines and by stress (Johnson and Lapadat, 2002; Shi and Gaestel, 2002). The p38 MAPK is thought to be particularly important in diseases like asthma and autoimmunity but it also plays important roles in the stress response of the nervous system (Philip and Armstead, 2003; Ying et al., 2002). Like the other MAPKs, p38 is activated by a dual specificity kinase that phosphorylates Thr¹⁸⁰ and Tyr¹⁸² (Lin et al., 1995).

Synonyms: ExpandCollapse

• CSAID Binding Protein 1 antibody
• CSAID binding protein antibody
• CSAID-binding protein antibody
• Csaids binding protein antibody
• CSBP 1 antibody
• CSBP 2 antibody
• CSBP antibody
• CSBP1 antibody
• CSBP2 antibody
• CSPB1 antibody
• Cytokine suppressive anti-inflammatory drug-binding protein antibody
• EXIP antibody
• MAP kinase 14 antibody
• MAP kinase MXI2 antibody
• MAP kinase p38 alpha antibody
• MAPK 14 antibody
• MAPK14 antibody
• MAX interacting protein 2 antibody
• MAX-interacting protein 2 antibody
• Mitogen Activated Protein Kinase 14 antibody
• Mitogen activated protein kinase p38 alpha antibody
• Mitogen-activated protein kinase 14 antibody
• Mitogen-activated protein kinase p38 alpha antibody
• MK14_HUMAN antibody
• Mxi 2 antibody
• MXI2 antibody
• p38 ALPHA antibody
• p38 antibody
• p38 MAP kinase antibody
• p38 MAPK antibody
• p38 mitogen activated protein kinase antibody
• p38ALPHA antibody
• p38alpha Exip antibody
• PRKM14 antibody
• PRKM15 antibody
• RK antibody
• SAPK2A antibody

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Product Specific References

Perrott, K.M., Wiley, C.D., Desprez, P.Y. and Campisi, J., 2017. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. GeroScience, pp.1-13. PMID: 28378188

Xu, P., Zhou, Z., Xiong, M., Zou, W., Deng, X., Ganaie, S.S., Kleiboeker, S., Peng, J., Liu, K., Wang, S. and Ye, S.Q., 2017. Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway. PLoS pathogens, 13(3), p.e1006266. PMID: 28264028

Alspach, E., Flanagan, K.C., Luo, X., Ruhland, M.K., Huang, H., Pazolli, E., Donlin, M.J., Marsh, T., Piwnica-Worms, D., Monahan, J. and Novack, D.V., 2014. p38MAPK plays a crucial role in stromal-mediated tumorigenesis. Cancer discovery, 4(6), pp.716-729. PMID: 24670723

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WB
IHC/IF

Western blot of HeLa cell lysates that had been treated with UV (~254 nm) for 0’ or 30’ showing the specific immunolabeling of the ~39 kDa p38 MAPK protein phosphorylated at Thr¹⁸⁰/Tyr¹⁸².

Immunostaining of human breast cancer tissue showing p38 when phosphorylated at Thr¹⁸⁰/Tyr¹⁸² in red. Photo courtesy of Patsy Ruegg.

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