- Formulation:
- Affinity Purified from Pooled Serum
- Species Tested:
- Human, Mouse
- Expected Reactivity:
- Rat, Bovine, Canine, Chicken, Non-human primate, Zebra fish
- Applications:
- WB 1:1000IHC 1:250 Don't see your application?
- Host Species:
- Rabbit Polyclonal
- Gene Name:
- MAPK14
- Molecular Weight:
- ~39 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# p190-1802, RRID:AB_2492195
Antigen/Purification: Collapse
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr180 and phospho-Tyr182 of rat p38 MAPK.
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Biological Significance: Collapse
The three Mitogen-Activated Protein Kinases (MAPKs) are evolutionarily conserved protein kinases that control a vast array of cellular processes. p38 MAPK is one of these kinases and it is activated by both inflammatory cytokines and by stress (Johnson and Lapadat, 2002; Shi and Gaestel, 2002). The p38 MAPK is thought to be particularly important in diseases like asthma and autoimmunity but it also plays important roles in the stress response of the nervous system (Philip and Armstead, 2003; Ying et al., 2002). Like the other MAPKs, p38 is activated by a dual specificity kinase that phosphorylates Thr180 and Tyr182 (Lin et al., 1995).
Synonyms: Collapse
• CSAID Binding Protein 1 antibody
• CSAID binding protein antibody
• CSAID-binding protein antibody
• Csaids binding protein antibody
• CSBP 1 antibody
• CSBP 2 antibody
• CSBP antibody
• CSBP1 antibody
• CSBP2 antibody
• CSPB1 antibody
• Cytokine suppressive anti-inflammatory drug-binding protein antibody
• EXIP antibody
• MAP kinase 14 antibody
• MAP kinase MXI2 antibody
• MAP kinase p38 alpha antibody
• MAPK 14 antibody
• MAPK14 antibody
• MAX interacting protein 2 antibody
• MAX-interacting protein 2 antibody
• Mitogen Activated Protein Kinase 14 antibody
• Mitogen activated protein kinase p38 alpha antibody
• Mitogen-activated protein kinase 14 antibody
• Mitogen-activated protein kinase p38 alpha antibody
• MK14_HUMAN antibody
• Mxi 2 antibody
• MXI2 antibody
• p38 ALPHA antibody
• p38 antibody
• p38 MAP kinase antibody
• p38 MAPK antibody
• p38 mitogen activated protein kinase antibody
• p38ALPHA antibody
• p38alpha Exip antibody
• PRKM14 antibody
• PRKM15 antibody
• RK antibody
• SAPK2A antibody
